Impact of Age on Mortality in Critically Ill Adult Patients in Nepal- a Single Center Retrospective Study of 5 Years.

NCT06888206 | Completed

• 1 other identifier: 400(6-11)E2- 081/082
• Study Type: observational
• Target: 8,189
• Locations: 1 country
• Sites: 1

Brief Summary

Rationale: Age is often considered a strong factor that determines the outcomes in critically ill patients. In a resource limited low middle income country (LMIC) like Nepal, the age factor is often considered when making treatment decisions by family especially when considering limiting treatment modalities. Whether or not this consideration of age for outcome prediction is appropriate however is a different discussion especially considering the fact that actual data from Nepalese ICUs are missing. Study Objective: To find the impact of age on mortality in critically ill patients. Design: A registry based, retrospective, descriptive study. Sample size: Convenience sampling of all the patients who are admitted to the ICU. Duration: Retrospective data from the 5-year period between November, 2019 to December, 2024. Place: Intensive care units (ICUs), Tribhuvan University Teaching Hospital (TUTH). Interventions: Not applicable Expected results: The study will help determine the mortality of the critically ill adult patients in terms of age.

Conditions

Effect of Age on Mortality; ICU Mortality; Age

Keywords

Age; Mortality; Intensive care unit; Low-middle income country

Outcome Measures

Primary Outcomes (1)

• All cause ICU mortality

  * To determine the all cause ICU mortality among rates among patients in ICU grouped according to Medical Subject Heading(MeSH) * Young adult: 19-24 years * Adult: 25-44 years * Middle aged: 45-64 years * Older adult (Senior): \>65 years * To determine the all cause ICU mortality among rates among patients in ICU grouped into decades * To determine the all cause ICU mortality among rates among patients \>65 years in ICU according to WHO classification of elderly * Young-old: 60-74 years * Old-old: 75- 84 years * Oldest-Old: \>85 years

  2019, November to 2024 December

Study Arms (4)

Young adult

Patients admitted to the ICU in the age group less than 24

Adult

Adults of the age group 25-44

Middle age

Patients of the age group 45-64

Older adult

Patients of the age group \>65 years

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients admitted to the ICUs of Tribhuvan University Teaching Hospital will be enrolled for this registry based retrospective study

You may qualify if:

• Age\>18 years Admission to the ICU

You may not qualify if:

• None

Sponsors & Collaborators

• Tribhuvan University Teaching Hospital, Institute Of Medicine.: lead

Study Sites (1)

Tribhuvan University Teaching Hospital

Mahārājgañj, Bagmati, 44600, Nepal

Location

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: March 15, 2025
• First Posted: March 21, 2025
• Study Start: November 1, 2019
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: March 25, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: March 2025- December 2025
• Access Criteria: All the de-identified patient data from the registry will be available to data handlers who will enter it in a format suitable for statistical analysis which will be available for the statistician for analysis.

Locations

NE (1)