Role of Elastic Power in Acute Respiratory Distress Syndrome

NCT06878313 | Not Yet Recruiting DMC

• 1 other identifier: UTIA El Cruce
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces. VILI results from the interaction between lung structure and mechanical ventilation factors, such as tidal volume, plateau pressure, driving pressure, inspiratory flow, respiratory rate, and PEEP. Intrinsic factors like lung heterogeneity further increase the risk. Elastic power (EP), a key component, is linked to repetitive alveolar stretching and disease progression. Study Objectives: Examine the correlation between elastic power and pulmonary hyperinflation. Compare EP's sensitivity and specificity with other overdistension markers like driving pressure, plateau pressure, upper inflection point, and compliance.

Conditions

ARDS (Moderate or Severe); Adult Patients

Keywords

ARDS; VILI; Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• Comparison between pulmonary hyperinflation and pulmonary elastic power

  1 hour

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients (≥18 years) with moderate-to-severe acute respiratory distress syndrome (ARDS) included in UCI.

You may not qualify if:

• History of emphysema, asthma, or pneumothorax.
• Severe instability at the time of the study preventing the PEEP titration maneuver, defined by at least one of the following indicators: SaO₂ ≤ 90%, shock requiring \>0.5 γ/kg/min of norepinephrine, complex arrhythmia, myocardial ischemia, or intracranial hypertension refractory to initial treatment.
• Patients with do-not-resuscitate orders and pregnant women.

Sponsors & Collaborators

• Hospital El Cruce: lead

Related Publications (4)

• Xie Y, Shi J, Liu S, Chen X, Wang Y, Li X, Yan Y. Association of elastic power in mechanical ventilation with the severity of acute respiratory distress syndrome: a retrospective study. Eur J Med Res. 2024 Jan 3;29(1):5. doi: 10.1186/s40001-023-01577-7.

  PMID: 38173033 BACKGROUND

• Modesto I Alapont V, Aguar Carrascosa M, Medina Villanueva A. Stress, strain and mechanical power: Is material science the answer to prevent ventilator induced lung injury? Med Intensiva (Engl Ed). 2019 Apr;43(3):165-175. doi: 10.1016/j.medin.2018.06.008. Epub 2018 Nov 5. No abstract available. English, Spanish.

  PMID: 30409677 BACKGROUND

• Marini JJ, Thornton LT, Rocco PRM, Crooke PS. From pressure to tension: a model of damaging inflation stress. Crit Care. 2023 Nov 15;27(1):441. doi: 10.1186/s13054-023-04675-4.

  PMID: 37968744 BACKGROUND

• Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. The future of mechanical ventilation: lessons from the present and the past. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x.

  PMID: 28701178 BACKGROUND

MeSH Terms

Conditions

Lymphoma, Follicular

Condition Hierarchy (Ancestors)

Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of intensive care

Study Record Dates

• First Submitted: March 11, 2025
• First Posted: March 14, 2025
• Study Start: April 1, 2025
• Primary Completion: April 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: March 14, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share