Force Control in Chronic Obstructive Pulmonary Disease

NCT06871670 | Completed

• 1 other identifier: 2025-CHITS-005
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Maximal muscle strength is one of the most commonly assessed neuromuscular parameters in people with COPD due to its accessibility and relevance for prescribing an appropriate workload for resistance training. However, maximal force production is very rarely necessary during daily activities which requires production of submaximal and precisely controlled forces. Despite growing research on motor impairments in COPD, very little attention has been given to the effect of this disease on force control. Therefore, this research aims to better understand the potential deficits in force control caused by COPD, through the use of advanced signal processing methods (i.e., nonlinear approaches). We hypothesized that force control would be reduced in people with COPD compared to healthy individuals, particularly at low force levels.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

COPD; Muscle; Force control; Non-linear; Variability; Isometric contractions

Outcome Measures

Primary Outcomes (1)

• Difference of the coefficient of variation (CV) of force signal between COPD patients and healthy participants for different contraction intensities.

  CV (%) is calculated as the ratio between standard deviation (SD) of force signal during muscle contraction and the mean produced force during the contraction.

  10-min

Secondary Outcomes (3)

• Difference of the root mean square error (RMSE) of force signal between COPD patients and healthy participants for different contraction intensities.

  10-min

• Difference of Sample Entropy (SampEn) of force signal between COPD patients and healthy participants for different contraction intensities.

  10-min

• Difference of Determinism (DET) from Recurrence Quantification Analysis (RQA) of force signal between COPD patients and healthy participants for different contraction intensities

  10-min

Study Arms (2)

Patients with COPD

Patients with chronic obstructive pulmonary disease

Other: Submaximal isometric contractions of knee extensors

Control participants

Healthy individuals

Other: Submaximal isometric contractions of knee extensors

Interventions

Submaximal isometric contractions of knee extensors OTHER

Brief isometric contractions performed at 10, 20, 30, 40, 50 and 60% of maximal voluntary force in a random order.

Control participants; Patients with COPD

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants enrolled in NEUROTIGUE study (NCT04028973)

You may qualify if:

• COPD patients :
• GOLD II - III or IV
• FEV1 \<80% of predicted values
• Men and women aged 40 years and over
• French-speaking participant
• BMI \<30 kg / m²
• Stable condition (i.e. without exacerbation) for more than 15 days
• Able to express their consent in writing prior to any participation in the study
• Affiliates or beneficiaries of a social security
• Minimum score of 26 on the MMSE questionnaire of 3 months or less
• Healthy volunteers :
• Men and women aged 40 years and over
• French-speaking participant
• BMI \<30 kg / m²
• No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies

You may not qualify if:

• COPD patients :
• Alcoholism, i.e. \> 21 glasses a week for men and \>14 glasses a week for women
• Psychiatric pathologies or antecedent of behavioral disorders
• Patients treated with oral or systemic corticosteroids (\> 0.5 mg / kg / day for \> 7 days)
• Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
• Severe vision or hearing problems not corrected
• Patient oxygen dependent
• Pregnant women (known pregnancy) or lactating women
• Patient deprived of liberty by a judicial or administrative decision
• Patient subject to a legal protection measure or unable to express their consent
• Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
• Patient unable to follow study procedures and to respect visits throughout the study period
• Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
• Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
• Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Sponsors & Collaborators

• Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer: lead
• Université de Toulon: collaborator

Study Sites (1)

Université de Toulon, laboratoires Laboratoire J-AP2S

Toulon, VAR, 83000, France

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jean-Marc Vallier, MD, PHD

  Université de Toulon

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 3, 2025
• First Posted: March 12, 2025
• Study Start: March 7, 2025
• Primary Completion: March 8, 2025
• Study Completion: March 8, 2025
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

FR (1)