Postural Control in Chronic Obstructive Pulmonary Disease

NCT06863246 | Completed

• 1 other identifier: 2025-CHITS-006
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Postural control impairment is common in people with COPD (pwCOPD), which can increase the risk of falls and affect quality of life. However, the majority of existing studies examine this postural control in isolation, without taking into account the cognitive demands that occur during activities of daily living during which individuals are often required to perform a mental task while maintaining their balance. This research aims to fill this gap by studying how a cognitive task can influence postural control in pwCOPD. We hypothesized an impaired postural control in pwCOPD compared to healthy individuals, which would be exacerbated in presence of a cognitive task.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

COPD; Postural control; Variability; Non-linear; Cognitive task; Static balance

Outcome Measures

Primary Outcomes (1)

• Difference of the range of COP displacement between groups and experimental conditions

  Range of COP displacement correspond to the maximal amplitude of the path of COP in anteroposterior and mediolateral directions.

  10 minutes

Secondary Outcomes (3)

• Difference of Sample Entropy (SampEn) of COP displacement between groups and experimental conditions

  10 minutes

• Difference of total COP displacement between groups and experimental conditions

  10 minutes

• Difference of area of COP displacement between groups and experimental conditions

  10 minutes

Other Outcomes (2)

• Difference of mean COP position between groups and experimental conditions

  10 minutes

• Difference of the mean speed of COP displacement between groups and experimental conditions

  10 minutes

Study Arms (2)

Patients with COPD

Patients with chronic obstructive pulmonary disease

Other: Evaluation of cognitive task on static balance; Other: Evaluation of visual feedback on static balance

Control participants

Healthy individuals

Other: Evaluation of cognitive task on static balance; Other: Evaluation of visual feedback on static balance

Interventions

Evaluation of cognitive task on static balance OTHER

Static balance with and without cognitive task (i.e., 1-back task)

Control participants; Patients with COPD

Evaluation of visual feedback on static balance OTHER

Static balance with and without visual feedback (i.e., eyes closed and open).

Control participants; Patients with COPD

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants enrolled in NEUROTIGUE study (NCT04028973)

You may qualify if:

• COPD patients :
• GOLD II - III or IV
• FEV1 \<80% of predicted values
• Men and women aged 40 years and over
• French-speaking participant
• BMI \<30 kg / m²
• Stable condition (i.e. without exacerbation) for more than 15 days
• Able to express their consent in writing prior to any participation in the study
• Affiliates or beneficiaries of a social security
• Minimum score of 26 on the MMSE questionnaire of 3 months or less
• Healthy volunteers :
• Men and women aged 40 years and over
• French-speaking participant
• BMI \<30 kg / m²
• No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies

You may not qualify if:

• COPD patients :
• Alcoholism, i.e. \> 21 glasses a week for men and \>14 glasses a week for women
• Psychiatric pathologies or antecedent of behavioral disorders
• Patients treated with oral or systemic corticosteroids (\> 0.5 mg / kg / day for \> 7 days)
• Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
• Severe vision or hearing problems not corrected
• Patient oxygen dependent
• Pregnant women (known pregnancy) or lactating women
• Patient deprived of liberty by a judicial or administrative decision
• Patient subject to a legal protection measure or unable to express their consent
• Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
• Patient unable to follow study procedures and to respect visits throughout the study period
• Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
• Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
• Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Sponsors & Collaborators

• Université de Toulon: collaborator
• Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer: lead

Study Sites (1)

Université de Toulon - Laboratoire J-AP2S

Toulon, VAR, 83100, France

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jean-Marc Vallier, MD, PHD

  Université de Toulon

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 3, 2025
• First Posted: March 7, 2025
• Study Start: March 7, 2025
• Primary Completion: March 8, 2025
• Study Completion: March 8, 2025
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

FR (1)