The Effect of Steep Trendelenburg Position on Neurocognitive Functions in Robotic Radical Prostatectomy Cases

NCT06869304 | Not Yet Recruiting

• 1 other identifier: TABED2-24-570
• Study Type: observational
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effects of the steep Trendelenburg position in robotic prostatectomy cases, where anesthesia depth is monitored using BIS and cerebral perfusion is tracked with NIRS, and to determine the incidence of neurocognitive dysfunction using the MoCA test in the postoperative period. Steep Trendelenburg position and CO₂ pneumoperitoneum during robotic radical prostatectomy lead to significant changes in intracranial pressure and cerebral oxygenation, which may contribute to postoperative neurocognitive dysfunction (POCD). Monitoring anesthesia depth with Bispectral Index (BIS) and cerebral perfusion with Near-Infrared Spectroscopy (NIRS) may help detect early neurocognitive changes, and MoCA test assessments will reveal a measurable decline in cognitive function postoperatively.

Conditions

Neurocognitive Disorder; Robotic Assisted Laparoscopic Radical Prostatectomy; Near Infrared Spectroscopy

Outcome Measures

Primary Outcomes (2)

• MoCA

  Preoperative MoCA test scores

  preoperatively

• MoCA

  postoperative MoCA test scores

  day 1

Secondary Outcomes (1)

• NIRS

  intraoperatively

Interventions

Montreal Cognitive Assessment DIAGNOSTIC_TEST

Preoperative and postoperative MoCA test scores

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 65 years and older with ASA II-III risk scores, undergoing robotic radical prostatectomy

You may qualify if:

• Age ≥ 65 years
• ASA II-III risk score
• Patients scheduled for robotic radical prostatectomy
• Patients who voluntarily agree to participate

You may not qualify if:

• Age \< 65 years
• History of neurological or psychiatric disorders
• Inability to undergo robotic surgery
• Conversion to open prostatectomy during surgery
• Patients who do not consent to participate

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara City Hospital Bilkent

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Neurocognitive Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Central Study Contacts

Betül Güven Aytaç, Assoc.prof.

CONTACT

+905073578351; drbguven@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof

Study Record Dates

• First Submitted: March 4, 2025
• First Posted: March 11, 2025
• Study Start: March 15, 2025
• Primary Completion: April 15, 2025
• Study Completion: October 30, 2025
• Last Updated: March 11, 2025

Record last verified: 2025-03

Locations

TU (1)