Acute Effects of Isoenergetic HIIE Vs. MICE on Key Parameters of Fat Mass Loss in Young Females with Overweight or Obesity

NCT06868862 | Recruiting

• 1 other identifier: CAAE: 79561024.4.0000.9487
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear. This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.

Conditions

Overweight and Obese Adults; High Intensity Interval Exercise (HIIE)

Keywords

oxygen consumption; high intensity interval training; substrate oxydation; catecholamines; obesity

Outcome Measures

Primary Outcomes (1)

• Oxygen consumption during exercise and the recovery period

  Determination of oxygen consumption during exercise and 2 hours after the exercise session (HIIE and MICE). Determination from Metamax (3D Cortex).

  Measurement at rest for 20 minutes, then during warm-up for 10 minutes, then during exercise for 20 minutes and finally during 2 hours after the end of the exercise.

Secondary Outcomes (4)

• Lipid before and after the exercise.

  Measurement at rest for 20 minutes and then during 2 hours after the end of the exercise.

• Carbohydrate before and after the exercise.

  Measurement at rest for 20 minutes and then during 2 hours after the end of the exercise.

• Catecholamines

  5 collections: before exercise started, at the end of exercise (exercise duration is 20-35 minutes), at 30 minutes, 60 minutes and 120 minutes after the end of exercise

• Energy intakes 24 hours after the exercise

  24 hours post exercise

Study Arms (2)

High Intensity Interval Exercise

EXPERIMENTAL

High Intensity Interval Exercise: 5 minutes of WarmUp + 10 x (1 minute at 85% HRmax followed by 1 minute of recovery at a power equivalent to 40% of HRmax)

Other: Exercise

Moderate Intensity Continuous Exercise

EXPERIMENTAL

Moderate Intensity Continuous Exercise: 5 minutes of WarmUp + 35 minutes at 55% HRmax

Other: Exercise

Interventions

Exercise OTHER

Two Exercise Modalities: HIIE and MICE

High Intensity Interval Exercise; Moderate Intensity Continuous Exercise

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• women with overwieght or obesity (BMI: 25-35 kg/m²)

You may not qualify if:

• contraceptive use
• menopause
• irregular menstrual cycle
• medical contraindications to intense physical activity,
• painful joints,
• taking ß-blocker

Sponsors & Collaborators

• Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques: lead
• LAPEF laboratory, Sao paulo: collaborator

Study Sites (1)

Laboratório de Fisiologia e Metabolismo Aplicados à Educação Física

São Paulo, São Paulo, 475, Brazil

RECRUITING

Related Publications (3)

• Dupuit M, Rance M, Morel C, Bouillon P, Pereira B, Bonnet A, Maillard F, Duclos M, Boisseau N. Moderate-Intensity Continuous Training or High-Intensity Interval Training with or without Resistance Training for Altering Body Composition in Postmenopausal Women. Med Sci Sports Exerc. 2020 Mar;52(3):736-745. doi: 10.1249/MSS.0000000000002162.

  PMID: 31524825 BACKGROUND

• Dupuit M, Boscaro A, Bonnet A, Bouillon P, Bruno P, Morel C, Rance M, Boisseau N. Acute metabolic responses after continuous or interval exercise in post-menopausal women with overweight or obesity. Scand J Med Sci Sports. 2020 Dec;30(12):2352-2363. doi: 10.1111/sms.13814. Epub 2020 Sep 18.

  PMID: 32881054 BACKGROUND

• Cunha FA, Midgley AW, McNaughton LR, Farinatti PT. Effect of continuous and intermittent bouts of isocaloric cycling and running exercise on excess postexercise oxygen consumption. J Sci Med Sport. 2016 Feb;19(2):187-92. doi: 10.1016/j.jsams.2015.02.004. Epub 2015 Feb 23.

  PMID: 25747467 BACKGROUND

MeSH Terms

Conditions

Overweight; Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Data collected on the volunteers will be made anonymous.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: March 11, 2025
• Study Start: February 1, 2025
• Primary Completion: December 30, 2025
• Study Completion: December 30, 2025
• Last Updated: March 11, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)