Investigation of the Relationship Between Executive Functions and Occupational Performance of Children With Duchenne Muscular Dystrophy

NCT06868784 | Enrolling By Invitation

• 1 other identifier: 2023025
• Study Type: observational
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The effects of Duchenne muscular dystrophy and its treatments on executive functions and occupational performance are under-mentioned in the literature. The researches believe that developmental and cognitive research is needed to identify interventions for children with DMD to identify and adapt to both individual and social environments, including self-care, productivity and leisure activities. Therefore, the aim of this study was to examine executive functions and occupational performance in children with DMD and compare them with healthy controls.

Conditions

Executive Dysfunction; Occupational Problems; Duchenne Muscular Dystrophy

Outcome Measures

Primary Outcomes (5)

• Demographic information form

  one-time evaluation

• Brooke upper extremity functional scale

  It will be used to assess the functional level of the upper limbs of children with DMD. The classification consists of six stages and progression from the first to the sixth stage indicates a decrease in the functionality of the upper limb.

  one-time evaluation

• Vignos lower extremity functional scale

  It will be used to assess the functional level of the lower limbs of children with DMD. The classification consists of ten stages and progression from the first to the tenth stage indicates a decrease in the functionality of the upper limb.

  one-time evaluation

• The Childhood Executive Functioning Inventory

  This 26-item scale consists of 4 subscales: working memory (9 items), planning (6 items), inhibition (6 items) and regulation (5 items). Working memory and planning sub-dimensions constitute the total score of "working memory" and inhibition and regulation sub-dimensions constitute the total score of "inhibition". As the score obtained from the scale increases, the child's executive functions weaken.

  one-time evaluation

• Canadian Occupational Performance Measure

  It will be used to assess children's occupational performance.

  one-time evaluation

Study Arms (2)

Children with Duchenne muscular dystrophy

Other: Evaluations

Healthy control group of children

Other: Evaluations

Interventions

Evaluations OTHER

Evaluations of executive functions and occupational performance

Children with Duchenne muscular dystrophy; Healthy control group of children

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

All boys diagnosed with DMD between the ages of 6-12 years constitute the population of this study.

You may qualify if:

• Being diagnosed with DMD
• Volunteering to participate in the study by their parents and reading and signing the informed consent form

You may not qualify if:

• Having a neuromuscular disease other than DMD and/or another diagnosed neuromuscular disease accompanying DMD
• The family and/or the child has problems with cooperation in completing the assessments for any reason
• Difficulty understanding and speaking the Turkish language

Sponsors & Collaborators

• Lokman Hekim University: lead

Study Sites (1)

Lokman Hekim University

Ankara, Çankaya, 06510, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Muscular Dystrophy, Duchenne

Condition Hierarchy (Ancestors)

Muscular Dystrophies; Muscular Disorders, Atrophic; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Genetic Diseases, X-Linked; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: May 10, 2024
• First Posted: March 11, 2025
• Study Start: March 1, 2025
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: February 23, 2026

Record last verified: 2026-02

Locations

TU (1)