Trials Sponsors Conditions Drugs Pricing

Conditions

Peri-Implantitis and Peri-implant Mucositis

Keywords

peri-implant sulcus fluidperi-implant diseasesLL-3725(OH)D

Outcome Measures

Primary Outcomes (5)

Peri-implant sulcus fluid vitamin D levels and clinical parameters correlation
The association between vitamin D levels in peri-implant sulcus fluid and clinical parameters in individuals with peri-implant health and peri-implant diseases.
At the day of visit (Day 0)- Peri-implant clinical assessments and peri-implant sulcus fluid collection
The correlation between vitamin D and the antimicrobial peptide LL-37
Peri-implant sulcus fluid Vitamin d and LL-37 levels were investigated with ELISA
Laboratory tests were completed after all samples were collected.
Mucosal Inflammation
Measurement of mucosal inflammation around implants using modified plaque index (mPI), and modified sulcus bleeding index (mSBI).
At the day of visit (Day 0)
Probing Pocket Depth
Measurement of the periodontal pockets depth around implants. Unit of Measure: Millimeters (mm)
At the day of visit (Day 0)
Width of Keratinized Mucosa
Measurement of the width of keratinized mucosa around the implants. Unit of Measure: Millimeters (mm)

Study Arms (1)

peri-implant healthy, peri-implant mucositis, peri-implantitis

A total of 105 dental implants from 33 patients were assessed, with 35 categorized in the peri-implant health group, 35 in the peri-implant mucositis group, and 35 in the peri-implantitis group.

Diagnostic Test: The patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay.

Interventions

The patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay.Diagnostic test

In vitro studies have shown that vitamin D promotes the release of antimicrobial peptides from gingival epithelial cells, no clinical research has specifically examined its effect on LL-37 levels in peri-implant tissue diseases. This study seeks to investigate the relationship between vitamin D levels in peri-implant sulcus fluid and clinical parameters in individuals with both peri-implant health and disease. Additionally, it aims to assess the correlation between vitamin D and the antimicrobial peptide LL-37.

peri-implant healthy, peri-implant mucositis, peri-implantitis

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

This cross-sectional clinical study included 33 patients with dental implants, exhibiting either healthy peri-implant tissues or peri-implant diseases, who sought treatment at the Department of Periodontology, Faculty of Dentistry, Altınbaş University.

You may qualify if:

Not received peri-implant treatment in the previous six months.

Sponsors & Collaborators

Altinbas University
Otherlead

Study Sites (1)

Altinbas University

Istanbul, BAKIRKOy, 34147, Turkey (Türkiye)

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peri-implant sulcus fluid

MeSH Terms

Conditions

Peri-Implantitis

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic Diseases

Study Officials

ILKNUR OZENCI, Dr
Altinbas University
PRINCIPAL INVESTIGATOR

Enrollment

33 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Target Duration: 1 Day
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Assistant professor

Study Record Dates

First Submitted

March 3, 2025

First Posted

March 10, 2025

Study Start

April 1, 2021

Actual (reported)

Peri-implant Vitamin D and Cathelicidin (LL-37) Levels

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (5)

Study Arms (1)

peri-implant healthy, peri-implant mucositis, peri-implantitis

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (5)

Study Arms (1)

peri-implant healthy, peri-implant mucositis, peri-implantitis

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations