Predictors of Survival of DKD Patients in Assiut University Hospital

NCT06865456 | Not Yet Recruiting

• 1 other identifier: DKD predictors
• Study Type: observational
• Target: 129
• Locations: 0 countries
• Sites: N/A

Brief Summary

In recent years, the global prevalence of diabetes has risen significantly. According to the 9th edition of the International Diabetes Federation Atlas, an estimated 463 million adults were living with diabetes in 2019, representing approximately 9.3% of the population, with an average annual increase of 51%. Diabetes is associated with multiple complications that can significantly impact patient outcomes . In 2019 alone, around 4.2 million deaths were attributed to diabetes and its complications, accounting for approximately 11.3% of all global deaths . In diabetic patients, several factors influence renal survival, including glycemic control, blood pressure management, lifestyle interventions, and pharmacological therapies such as renin-angiotensin-aldosterone system (RAAS) inhibitors, sodium-glucose co-transporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists(9). Early detection of kidney dysfunction through biomarkers like estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) plays a pivotal role in improving renal outcomes. This study aims to evaluate the factors affecting Patients survival in diabetic patients, identify early predictors of renal function decline, and assess the effectiveness of current therapeutic strategies.

Conditions

Chronic Kidney Disease(CKD)

Keywords

diabetic nephropathy

Outcome Measures

Primary Outcomes (1)

• incidence of CKD in diabetic patients

  pergentage of diabetic patients with stage 4,5 chronic kidney disease

  baseline

Study Arms (1)

study group

diapetic patient with diabetic nephropathy stage 4,5

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

diabetic patients with chronic kideny disease stage 4,5

You may qualify if:

• ● Patients age \> 18 years old
• Both sex
• diabetic patients with HbA1c level \>6.5( Type 1 and 2)
• Diabetic patients with CKD 4, 5 )
• HD Pt

You may not qualify if:

• ● Chronic kidney diseases stage 1,2, and 3.
• Acute kidney injury.
• Patients with any other causes of CKD autoimmune disease

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Diabetic Nephropathies

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: residant doctor at Assiut university hospital

Study Record Dates

• First Submitted: March 4, 2025
• First Posted: March 7, 2025
• Study Start: May 1, 2025
• Primary Completion: May 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: March 7, 2025

Record last verified: 2025-03