Effect of Different Sealers and Activation Methods on Pain

NCT06860191 | Not Yet Recruiting Phase 4

• 1 other identifier: 2025/1
• Study Type: interventional
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this study, the effects of different irrigation agitation methods and different root canal filling sealers on postoperative pain after root canal treatment will be evaluated.

Conditions

Chronic Apical Periodontitis

Keywords

Caries; apical periodontitis; irrigation agitation; root canal sealer

Outcome Measures

Primary Outcomes (1)

• Pain symptoms of the patients will be evaluated with prepared questionnaires, and periapical lesion healing will be evaluated with periapical radiographs. A visual analog scale will be used to measure the degree of pain.

  Performing clinical and radiographic follow-up and evaluation of the patient.A visual analog scale will be used to measure the degree of pain.

  1-4 months

Study Arms (4)

Ah plus+MDA

EXPERIMENTAL

Ah plus will be used as the root canal sealer and manual dynamic activation will be used for irrigation agitation.

Drug: Root Canal Sealants

Ah plus+PUA

EXPERIMENTAL

Ah plus will be used as the root canal sealer and pasive ultrasonic agitation will be used for irrigation agitation.

Drug: Root Canal Sealants

Neosealer Flo+MDA

EXPERIMENTAL

Neosealer Flo will be used as the root canal sealer and manual dynamic activation will be used for irrigation agitation.

Drug: Root Canal Sealants

Neosealer Flo+PUA

EXPERIMENTAL

Neosealer Flo will be used as the root canal sealer and pasive ultrasonic agitation will be used for irrigation agitation.

Drug: Root Canal Sealants

Interventions

Root Canal Sealants DRUG

In this study, different irrigation agitation methods and different root canal sealers will be compared.

Ah plus+MDA; Ah plus+PUA; Neosealer Flo+MDA; Neosealer Flo+PUA

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years who are classified as medically healthy (ASA I or II),
• Teeth that do not need periodontal and prosthetic treatment, with a periapical index score between 2 and 4,
• Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
• Teeth that respond negatively to electric pulp test (Parkell) or cold test (Endo Ice; Coltene, Altstätten, İsviçre), without pain during percussion and palpation.

You may not qualify if:

• Teeth with PAI scores lower than 2
• Patients who had taken analgesics or anti-inflammatory drugs in the last 4 hours
• Diabetic, immunocompromised, pregnant or history of antibiotic use in the last month or patients receiving antibiotic prophylaxis
• Teeth with root resorption, immature, severe crown damage, calcified canals, and previous root canal fillings

Sponsors & Collaborators

• TC Erciyes University: lead

MeSH Terms

Conditions

Periapical Periodontitis

Interventions

Root Canal Filling Materials

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis

Intervention Hierarchy (Ancestors)

Dental Materials; Biomedical and Dental Materials; Manufactured Materials; Technology, Industry, and Agriculture

Central Study Contacts

İpek A ERASLAN AKYÜZ

CONTACT

+9 5385591409; ipekemamak@hotmail.com

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research assistant

Study Record Dates

• First Submitted: February 1, 2025
• First Posted: March 5, 2025
• Study Start: March 1, 2025
• Primary Completion: March 1, 2025
• Study Completion: May 1, 2025
• Last Updated: March 5, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share