NCT06858358

Brief Summary

This multicenter, prospective cohort study will evaluate whether Robotic-Assisted total knee arthroplasty (RATKA) with a Medial Congruent implant is a successful method to improve implant alignment, insert thickness accuracy, and patient satisfaction, compared to a conventional TKA (cTKA) Medial Pivot technique. It aims to assess and compare clinical and functional outcomes in patients with severe knee osteoarthritis at 3, 6, and 12 months.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for not_applicable

Timeline
3mo left

Started Feb 2025

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress79%
Feb 2025Sep 2026

First Submitted

Initial submission to the registry

February 21, 2025

Completed
3 days until next milestone

Study Start

First participant enrolled

February 24, 2025

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 5, 2025

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

March 5, 2025

Status Verified

February 1, 2025

Enrollment Period

1.3 years

First QC Date

February 21, 2025

Last Update Submit

February 27, 2025

Conditions

Keywords

RoboticKnee arthroplastyTKAROSA

Outcome Measures

Primary Outcomes (2)

  • Polyethylene insert thickness

    Insert Thickness: Measured and analyzed in millimeters

    Perioperative/ Periprocedural

  • Mechanical axis outliers

    Outliers: Defined as more than 2.0 degrees from mechanical alignment, measured on full-leg X-ray

    Perioperative/ Periprocedural

Secondary Outcomes (2)

  • International knee documentation committe (IKDC) subjective score

    3, 6, and 12 months post-operative

  • Forgotten joint score-12 (FJS-12)

    3, 6, and 12 months post-operative

Study Arms (2)

ROSA Robotic-assisted TKA with Zimmer Biomet Persona Medial Congruent implant

EXPERIMENTAL
Procedure: Robotic assisted total knee arthroplasty

Conventional TKA with Microport Evolution Medial-Pivot

EXPERIMENTAL
Procedure: Conventional total knee arthroplasty (cTKA)

Interventions

• ROSA RATKA with Zimmer Biomet Persona Medial Congruent

ROSA Robotic-assisted TKA with Zimmer Biomet Persona Medial Congruent implant

cTKA with Microport Evolution Medial-Pivot

Conventional TKA with Microport Evolution Medial-Pivot

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with severe osteoarthritis (greater than III Ahlback)

You may not qualify if:

  • Patients who refuse participation in the study Low-grade osteoarthritis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

MedLife Humanitas Hospital

Cluj-Napoca, Cluj, 400664, Romania

RECRUITING

Medicover Cluj Hospital

Cluj-Napoca, Cluj, 407062, Romania

RECRUITING

Central Study Contacts

Razvan M Melinte, MD, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

February 21, 2025

First Posted

March 5, 2025

Study Start

February 24, 2025

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

March 5, 2025

Record last verified: 2025-02

Locations