NCT06857630

Brief Summary

Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. The effects of hemoglobin levels in emergency surgery patients on the development of postoperative AKI have been investigated in a small number of studies in the literature, and clear results have not yet been reported. This study was designed to evaluate the effect of hemoglobin levels on the development of AKI after adjustment for known predictive factors.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
420

participants targeted

Target at P75+ for all trials

Timeline
12mo left

Started Jan 2025

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress58%
Jan 2025May 2027

Study Start

First participant enrolled

January 1, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

February 20, 2025

Completed
12 days until next milestone

First Posted

Study publicly available on registry

March 4, 2025

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2027

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2027

Last Updated

March 17, 2026

Status Verified

March 1, 2026

Enrollment Period

2.2 years

First QC Date

February 20, 2025

Last Update Submit

March 13, 2026

Conditions

Acute Kidney InjuryHemoglobinEmergency Surgery

Keywords

Acute kidney injuryEmergency surgeryRisk factorHemoglobin

Outcome Measures

Primary Outcomes (1)

  • Acute renal failure.

    The effect of hemoglobin level before emergency surgery on the development of postoperative acute renal failure.

    72 hours

Secondary Outcomes (1)

  • Hospital days

    1 month

Study Arms (2)

Group AKI

Postoperative renal failure

Other: Observational

Group non-AKI

Postoperative non renal failure

Other: Observational

Interventions

ObservationalOTHER

Postoperative acute kidney injury and hemoglobin level relationship observation

Group AKIGroup non-AKI

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients undergoing emergency non-cardiac surgery

You may qualify if:

  • Patients undergoing emergency non-cardiac surgery

You may not qualify if:

  • Known renal failure
  • Need for reoperation within 48 hours postoperatively
  • Exit status within 48 hours postoperatively
  • Known hematological disease
  • Known kidney transplantation
  • Urgent surgery planned due to urinary system related diseases
  • Patients who did not accept to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Özgür Kömürcü

Samsun, 55200, Turkey (Türkiye)

RECRUITING

Related Publications (3)

  • Meersch M, Schmidt C, Zarbock A. Perioperative Acute Kidney Injury: An Under-Recognized Problem. Anesth Analg. 2017 Oct;125(4):1223-1232. doi: 10.1213/ANE.0000000000002369.

    PMID: 28787339BACKGROUND

  • Grams ME, Sang Y, Coresh J, Ballew S, Matsushita K, Molnar MZ, Szabo Z, Kalantar-Zadeh K, Kovesdy CP. Acute Kidney Injury After Major Surgery: A Retrospective Analysis of Veterans Health Administration Data. Am J Kidney Dis. 2016 Jun;67(6):872-80. doi: 10.1053/j.ajkd.2015.07.022. Epub 2015 Sep 1.

    PMID: 26337133BACKGROUND

  • Cabezuelo JB, Ramirez P, Rios A, Acosta F, Torres D, Sansano T, Pons JA, Bru M, Montoya M, Bueno FS, Robles R, Parrilla P. Risk factors of acute renal failure after liver transplantation. Kidney Int. 2006 Mar;69(6):1073-80. doi: 10.1038/sj.ki.5000216.

    PMID: 16528257BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury

Interventions

Watchful Waiting

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

Outcome Assessment, Health CareOutcome and Process Assessment, Health CareQuality of Health CareHealth Services Administration

Study Officials

  • özgür kömürcü, 1

    Samsun University

    STUDY DIRECTOR

Central Study Contacts

özgür kömürcü, 1

CONTACT

90 5055273180zgrkom@gmail.com

özgür kömürcü, 2

CONTACT

90 505 5273180zgrkom@gmail.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 20, 2025

First Posted

March 4, 2025

Study Start

January 1, 2025

Primary Completion (Estimated)

March 1, 2027

Study Completion (Estimated)

May 1, 2027

Last Updated

March 17, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)