The Association Between Microplastics and Macrogenomics and Metabolomics in Gastric Cancer

NCT06856382 | Active Not Recruiting DMC

• 1 other identifier: 2024-530-01
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to identify and quantify microplastics in blood, stool, and tumor surgical specimens from gastric cancer patients by analyzing the nature, type, and abundance of microplastics using laser direct infrared (LDIR) spectroscopy, scanning electron microscopy (SEM), and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS). Meanwhile, combining macro-genomic and metabolomic techniques to explore the association between microplastics and host microbiota and metabolic profiles, and to reveal the potential effects of microplastics on gastric cancer incidence and development will provide new insights into the relationship between microplastic contamination and gastric cancer, as well as an important scientific basis for future public health strategies and cancer prevention and control measures.

Conditions

Gastric Cancers

Keywords

Gastric cancer; Microplastics; Macrogenomic; Metabolomics; Microenvironment

Outcome Measures

Primary Outcomes (1)

• Types of microplastics in gastric cancerous and paracancerous tissues (categorical measure)

  Polymer types of microplastics in gastric tissues Time Frame: Intraoperative sampling Measuring tool: μ-FTIR spectroscopy Unit: Categorical classification (e.g., polyethylene, polypropylene, etc.)

  The date of microplastics testing, assessed up to 1 week after surgery.

Secondary Outcomes (2)

• Physical-chemical properties of microplastics in gastric cancerous and paracancerous tissues (continuous measure)

  The date of microplastics testing, assessed up to 1 week after surgery.

• Abundance of microplastics in gastric cancerous and paracancerous tissues (count/particles per gram)

  The date of microplastics testing, assessed up to 1 week after surgery.

Study Arms (1)

the gastric cancer group

patients diagnosed with gastric cancer

Diagnostic Test: gastric cancer

Interventions

gastric cancer DIAGNOSTIC_TEST

Patients diagnosed with gastric cancer by pathological biopsy.

the gastric cancer group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with colorectal cancer by pathological biopsy were included in the study.

You may qualify if:

• age ≥18 years old;
• diagnosed with gastric cancer by pathology before surgery and not receiving chemotherapy, radiotherapy or immunotherapy;
• no history of other gastrointestinal diseases;
• complete clinical data and basic information;
• willing to participate in this study and sign an informed consent form.

You may not qualify if:

• Patients receiving neoadjuvant radiotherapy or chemotherapy;
• patients with other malignant tumors other than gastric cancer;
• patients with incomplete or unclear pathological data;
• individuals who are not willing to participate in the study.

Sponsors & Collaborators

• Dong Peng: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

surgically resected tissue and serum

MeSH Terms

Conditions

Stomach Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 25, 2025
• First Posted: March 4, 2025
• Study Start: December 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 4, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)