Pharmacogenomics to Improve Supportive Care Symptoms.

NCT06856122 | Enrolling By Invitation

• 1 other identifier: 2024GRANT089
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

To understand the clinical utility of multi-gene pharmacogenetic testing in patients receiving palliative and supportive care across palliative care settings (inpatient hospital, outpatient), specifically to calculate a drug-gene interaction ratio, based on extant prescriptions paired with an individual's pharmacogenetic results.

Conditions

Palliative Care; Supportive Care

Keywords

Pharmacogenomics; pharmacogenetics; palliative; supportive care

Outcome Measures

Primary Outcomes (1)

• Drug-gene interaction ratio (DGI)

  The total number of genetic variation results that pair with a relevant prescribed medication for that same individual, divided by total number of individuals tested.

  This will be calculated for all current medications prescribed at the point of recruitment.

Secondary Outcomes (1)

• Frequency of changes in prescription medication that are potentially affected by drug-gene interaction

  from enrolment until 90 days post blood test

Study Arms (1)

Study participants

Patients with serious and/or life limiting condition conditions, such as incurable cancer undergoing palliative or supportive care treatment. They will have a 5mL blood sample collected.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will be from Norfolk and Norwich University Hospitals NHS Foundation Trust

Sponsors & Collaborators

• Norfolk and Norwich University Hospitals NHS Foundation Trust: lead
• Manchester Centre for Genomic Medicine - St. Mary's Hospital University of Manchester: collaborator

Study Sites (2)

Norfolk and Norwich University Hospitals NHS Foundation Trust

Norwich, Norfolk, NR4 7UY, United Kingdom

Location

The Manchester Centre for Genomic Medicine

Manchester, M13 9WL, United Kingdom

Location

Related Publications (1)

• Barry C, Patel M. Pharmacogenomics and symptom management in palliative and supportive care: A scoping review. BMJ Support Palliat Care. 2025 Feb 26;15(2):158-167. doi: 10.1136/spcare-2024-005205.

  PMID: 39805678 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample

Study Officials

• Dr Martyn Patel

  Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)

  PRINCIPAL INVESTIGATOR

• Dr Caroline Barry

  Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2025
• First Posted: March 4, 2025
• Study Start: May 9, 2025
• Primary Completion: April 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: July 14, 2025

Record last verified: 2025-02

Locations

GB (2)