the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes

NCT06852495 | Active Not Recruiting DMC

• 1 other identifier: 2024-443-01
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.

Conditions

Colon Cancer; Rectal Cancer

Keywords

Colorectal cancer; Macrogenome; Environmental pollution; air pollution

Outcome Measures

Primary Outcomes (1)

• prognosis

  Overall survival (OS), from date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first.

  From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months

Secondary Outcomes (1)

• Macrogenomic differences

  The date of macrogenomic testing, assessed up to 1 week after surgery.

Study Arms (2)

the colorectal cancer group

patients diagnosed with colorectal cancer

the control group

Healthy individuals with no history of malignant tumor

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with colorectal cancer by pathological biopsy and healthy participants with no history of malignancy were included in the study.

You may qualify if:

• Age ≥18 years old;
• Patients diagnosed with colorectal cancer by pathologic biopsy before surgery;
• Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
• Willing to participate in the study and sign an informed consent form. Complete clinical data.

You may not qualify if:

• Concurrent primary malignant tumor other than colorectal cancer;
• Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan;
• Inappropriate for enrollment as assessed by the investigator;
• Incomplete clinical data.

Sponsors & Collaborators

• Dong Peng: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Feces

MeSH Terms

Conditions

Colonic Neoplasms; Rectal Neoplasms; Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 25, 2025
• First Posted: February 28, 2025
• Study Start: November 1, 2024
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): November 1, 2027
• Last Updated: February 28, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)