Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models

NCT06848959 | Recruiting DMC

• 2 other identifiers: HospitalNanjingUNanjing Science and Technology
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood encephalopathy and a follow-up tracking question and answer system for childhood encephalopathy patients.

Conditions

Cerebral Palsy; Mental Retardation; Tourette's Syndrome; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorders

Outcome Measures

Primary Outcomes (14)

• Childhood Autism Rating Scale

  The total score ranges from 15 to 60, with the higher the score the worse the symptoms are

  4 mouths

• meridian and acupointological features

  After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  4 mouths

• Yale Global Tic Severity Scale

  It has a score range of 0-100, with higher scores representing more severe symptoms.

  4 mouths

• Gross Motor Function Assessment Scale (GMFM)-88

  GMFM-88 scores range from 0-264, with higher scores being better.

  4 mouths

• Autism Behavior Checklist

  It has a score range of 0-174, with higher scores representing more severe symptoms.

  4 mouths

• acupuncture point status

  After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  4 mouths

• Tongue texture

  After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  4 mouths

• Wechsler intelligence scale (WIS)

  FIQ = 100: Indicates that the individual has an average level of intelligence. FIQ \> 100: Indicates an above average level of intelligence. FIQ \< 100: Indicates a below average level of intelligence.

  4 mouths

• Resting heart rate

  4 mouths

• blood pressure (systolic, diastolic) after 10 minutes of rest

  4 mouths

• Conners Rating Scales

  Scores are converted to standardized T-scores for comparison with the mean of the peer group. T-scores above 65 are usually considered clinically significant.

  4 mouths

• tongue coating, pulse

  After obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of "Pediatrics of Chinese Medicine".

  4 mouths

• respiratory rate

  4 mouths

• Body temperature

  4 mouths

Secondary Outcomes (4)

• Saliva

  4 mouths

• blood

  4 mouths

• Urine

  4 mouths

• Faeces

  4 mouths

Interventions

No intervention OTHER

Pediatric Encephalopathy Science and Prevention Decision Aid Follow-Up Q\&A

Eligibility Criteria

• Age: 2 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Childhood encephalopathy

You may qualify if:

• \. meet diagnostic criteria for CP ID TD ADHD ASD; 2. gender is not limited;

You may not qualify if:

• \. CP ID TD ASD due to chorea hepatomegaly hearing abnormality and pharmacogenetic factors;
• \. Children with other major mental illnesses (e.g. schizophrenia) or organic diseases (e.g. congenital heart disease);

Sponsors & Collaborators

• Yun Liu,PhD: lead

Study Sites (1)

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Nanjing, China

RECRUITING

MeSH Terms

Conditions

Cerebral Palsy; Intellectual Disability; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders; Attention Deficit and Disruptive Behavior Disorders; Child Development Disorders, Pervasive

Central Study Contacts

Yun Liu PhD

CONTACT

+86 13023876996; 20200413@njucm.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: February 18, 2025
• First Posted: February 27, 2025
• Study Start: January 1, 2024
• Primary Completion: February 28, 2025
• Study Completion: December 31, 2025
• Last Updated: February 27, 2025

Record last verified: 2025-02

Locations

CN (1)