Proton Pump Inhibitor Use and Dental Implant Success

NCT06848855 | Completed

• 1 other identifier: 2023/295
• Study Type: observational
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the effects of proton pump inhibitors (PPIs) on the surrounding bone and the survival of dental implants. The main questions it aims to answer are: Does PPI use affect the survival rate of dental implants? Does PPI use influence crestal bone loss and fractal dimension (FD) of the surrounding bone?

Conditions

Implant Survival Rate; Implant Survival and Success

Outcome Measures

Primary Outcomes (1)

• Fractal Dimension Value

  Fractal analysis values were calculated on radiographs within 1 month after the data collection of the patients.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study was conducted with patients who had a history of PPI use for more than six months and systemically healthy individuals who had undergone regular clinical and radiological follow-ups after dental implant placement at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University.

You may qualify if:

• Being over 18 years old,
• Having a history of PPI use for more than six months,
• Having at least one bone-level and axially placed dental implant in the maxilla or mandible,
• Having a minimum of one year elapsed since the prosthetic restoration following dental implant placement,
• Having undergone routine clinical follow-ups and radiological evaluations with periapical radiographs taken using the parallel cone technique after dental implant placement.

You may not qualify if:

• Individuals with a history of PPI use for less than six months,
• Individuals with periapical radiographs of low image quality or with artifacts,
• Individuals for whom the regions selected for fractal analysis on periapical radiographs are not appropriately sized,
• Individuals who have not undergone routine clinical and radiographic follow-ups.

Sponsors & Collaborators

• Berkay Tokuç: lead

Study Sites (1)

Kocaeli University

Kocaeli, 41040, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 23, 2025
• First Posted: February 27, 2025
• Study Start: November 1, 2023
• Primary Completion: April 15, 2024
• Study Completion: May 15, 2024
• Last Updated: February 27, 2025

Record last verified: 2025-02

Locations

TU (1)