Transfusion Prediction in Major Abdominal Surgery

NCT06847490 | Completed

• 1 other identifier: AMC (2024-1087)
• Study Type: observational
• Target: 128,749
• Locations: 1 country
• Sites: 1

Brief Summary

The transfusion nomogram, integrating preoperative variables, may effectively predict intraoperative transfusion in major abdominal surgery.

Conditions

Transfusions

Outcome Measures

Primary Outcomes (1)

• Intraoperative transfusion

  The primary outcome measure is the occurrence of intraoperative blood transfusion. This includes any administration of red blood cells, plasma, or platelets during the surgical procedure. The study aims to predict transfusion requirements based on preoperative clinical factors.

  From surgical incision to the end of surgery

Interventions

No intervention (observational study) OTHER

This is an observational study aimed at developing and validating a predictive model for perioperative blood transfusion. The study utilizes retrospective clinical data from surgical patients to identify key risk factors associated with transfusion requirements. No experimental intervention will be applied to participants, as the study solely focuses on data analysis and model development.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes adult patients (≥18 years old) who underwent major abdominal surgery at a tertiary medical center. The study population consists of patients with available preoperative clinical and laboratory data, allowing for the development of a predictive model for intraoperative blood transfusion. Patients with known hematologic disorders, coagulopathy, or prior transfusion before surgery are excluded to minimize confounding factors.

You may qualify if:

• Patients aged 18 years and older who underwent major abdominal surgery

You may not qualify if:

• Patients with known hematologic disease or coagulopathy
• Patients who received a blood transfusion before surgery
• Patients with incomplete data or missing laboratory values

Sponsors & Collaborators

• Asan Medical Center: lead

Study Sites (1)

Asan Medical Center

Seoul, Songpa, 05505, South Korea

Location

Related Publications (1)

• Sim JH, Oh AR, Kim S, Park YS, Ha S, Kim JU. Development and validation of a predictive model for transfusion in major abdominal surgery: a multicentre retrospective study. Br J Anaesth. 2025 Sep;135(3):623-631. doi: 10.1016/j.bja.2025.05.048. Epub 2025 Jul 18.

  PMID: 40681389 DERIVED

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: February 26, 2025
• Study Start: June 30, 2024
• Primary Completion: December 20, 2024
• Study Completion: January 2, 2025
• Last Updated: February 26, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)