Intra-Abdominal Sepsis and Relationship Between Cumulative Fluid Balance and Serum Sodium and Chloride Levels and In-Hospital Mortality

NCT06838585 | Completed

• 1 other identifier: 00-108
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Intra-abdominal sepsis and septic shock in critically ill surgical patients have a high mortality rate. Fluid therapy is one of the initial resuscitation measures, but it can contribute to poor treatment outcomes through fluid overload and accumulation of sodium and chloride. This study aimed to examine an association among cumulative fluid balance and serum sodium and chloride levels in the intensive care unit (ICU) and in-hospital mortality in critically ill surgical patients with intra-abdominal sepsis after emergency surgical treatment. The study was designed as a retrospective, cohort study.

Conditions

Intraabdominal Infections; Fluid Balance; Disorder; Sodium Disorder; Chloride Disorder

Keywords

sepsis; intra-abdominal sepsis; in-hospital mortality; fluid therapy; sodium disorder; chloride disorder; critically ill patients

Outcome Measures

Primary Outcomes (1)

• Association among cumulative fluid balance and serum sodium and chloride levels in the intensive care unit (ICU) and in-hospital mortality in critically ill surgical patients with intra-abdominal sepsis after emergency surgical treatment.

  This study aimed to examine an association among cumulative fluid balance and serum sodium and chloride levels in the intensive care unit (ICU) and in-hospital mortality in critically ill surgical patients with intra-abdominal sepsis after emergency surgical treatment.

  2 years

Interventions

infusion therapy PROCEDURE

Monitoring patients with fluid overload and fluid accumulation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

100 critically ill surgical patients with intra-abdominal sepsis, consecutively admitted to the ICU of a university medical center. Patients were immediately subjected to surgical treatment for intra-abdominal sepsis upon hospital admission. Postoperative care continued in the ICU for at least seven days.

You may qualify if:

• critically ill surgical patients with intra-abdominal sepsis/septic shock consecutively admitted to a university medical center
• Patients who were immediately subjected to surgical treatment for intra-abdominal sepsis/sepstic shock upon hospital admission and postoperative care continued in the ICU for at least seven days

You may not qualify if:

• Patients who were hospitalized in the ICU for less than seven days
• immunocompromised
• patients with intra-abdominal sepsis as a result of previous abdominal surgery were not included in the study

Sponsors & Collaborators

• Clinical Center of Vojvodina: lead

Study Sites (1)

Clinical Center of Vojvodina

Novi Sad, Serbia, Serbia

Location

Related Publications (1)

• Popovic R, Andelic N, Jovanovic G, Maricic Prijic S, Uvelin A, Tomic N, Plecas Ethuric A, Todorovic N, Milijasevic B, Markovic D. Intra-abdominal sepsis in critically ill surgical patients: the relationship between cumulative fluid balance and serum sodium and chloride levels and in-hospital mortality. Front Med (Lausanne). 2025 Jul 16;12:1608388. doi: 10.3389/fmed.2025.1608388. eCollection 2025.

  PMID: 40740943 DERIVED

MeSH Terms

Conditions

Intraabdominal Infections; Sepsis

Interventions

Home Infusion Therapy

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Drug Therapy; Therapeutics; Home Care Services; Community Health Services; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Radmila N Popovic, MD, PhD

  University Clinical Center of Vojvodina

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: February 20, 2025
• Study Start: June 1, 2022
• Primary Completion: September 1, 2024
• Study Completion: October 15, 2024
• Last Updated: February 20, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)