Prognostic Value of Proadrenomedullin in Intra-abdominal Sepsis

NCT03061500 | Unknown

• 1 other identifier: PI2289
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.

Conditions

Intraabdominal Infections

Keywords

Proadrenomedullin; Sepsis; Intraabdominal Infections; prognosis

Outcome Measures

Primary Outcomes (1)

• mortality

  30 days

Secondary Outcomes (4)

• days of stay in critical units

  30 days

• days of mechanical ventilation

  30 days

• days of need vasopressors

  30 days

• days of need for renal replacement techniques

  30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Intraabdominal sepsis patients after damage control surgery

You may qualify if:

• All patients consecutively collected, adults over 18, who are admitted to critical care unit with the diagnosis of localized or generalized intraabdominal infection after damage control surgery.

You may not qualify if:

• Pregnant or lactating women.
• Patients with neutropenia induced by bone marrow transplant or by chemotherapy (\<500 neutrophils / ml).

Sponsors & Collaborators

• Instituto de Investigación Hospital Universitario La Paz: lead

Study Sites (1)

Hospital Universitario de la Paz

Madrid, Madrid, 28046, Spain

RECRUITING

Related Publications (5)

• Espana PP, Capelastegui A, Mar C, Bilbao A, Quintana JM, Diez R, Esteban C, Bereciartua E, Unanue U, Uranga A. Performance of pro-adrenomedullin for identifying adverse outcomes in community-acquired pneumonia. J Infect. 2015 May;70(5):457-66. doi: 10.1016/j.jinf.2014.12.003. Epub 2014 Dec 11.

  PMID: 25499199 BACKGROUND

• Bello S, Lasierra AB, Minchole E, Fandos S, Ruiz MA, Vera E, de Pablo F, Ferrer M, Menendez R, Torres A. Prognostic power of proadrenomedullin in community-acquired pneumonia is independent of aetiology. Eur Respir J. 2012 May;39(5):1144-55. doi: 10.1183/09031936.00080411. Epub 2011 Nov 10.

  PMID: 22075489 BACKGROUND

• Cavallazzi R, El-Kersh K, Abu-Atherah E, Singh S, Loke YK, Wiemken T, Ramirez J. Midregional proadrenomedullin for prognosis in community-acquired pneumonia: a systematic review. Respir Med. 2014 Nov;108(11):1569-80. doi: 10.1016/j.rmed.2014.09.018.

  PMID: 25448309 BACKGROUND

• Suberviola B, Castellanos-Ortega A, Llorca J, Ortiz F, Iglesias D, Prieto B. Prognostic value of proadrenomedullin in severe sepsis and septic shock patients with community-acquired pneumonia. Swiss Med Wkly. 2012 Mar 19;142:w13542. doi: 10.4414/smw.2012.13542. eCollection 2012.

  PMID: 22430899 BACKGROUND

• Christ-Crain M, Morgenthaler NG, Struck J, Harbarth S, Bergmann A, Muller B. Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care. 2005;9(6):R816-24. doi: 10.1186/cc3885. Epub 2005 Nov 15.

  PMID: 16356231 BACKGROUND

MeSH Terms

Conditions

Intraabdominal Infections; Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ana Maria Montero Feijoo

CONTACT

+34696079362; anamonterofeijoo@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: February 19, 2017
• First Posted: February 23, 2017
• Study Start: October 15, 2016
• Primary Completion: October 15, 2017
• Study Completion: October 15, 2017
• Last Updated: February 23, 2017

Record last verified: 2017-02

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)