Lung Cancer Screening CT for Firefighters

NCT06836414 | Withdrawn DMC

• 2 other identifiers: 24053NCI-2025-00336
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. This study aims to provide chest computed tomography (CT) scans to firefighters to determine the prevalence of lung cancer, other cancers detectable on CT chest, and lung diseases associated with increased cancer risk.

Conditions

Exposure, Inhalation; Exposure to Pollution; Lung Diseases; Occupational Lung Disease; Smoke Inhalation; Exposure Occupational; Lung Cancer; Lung Diseases, Interstitial; Occupational Exposure; Interstitial Lung Disease

Keywords

Population research; Cancer Screening

Outcome Measures

Primary Outcomes (5)

• Proportion of participants with detected lung cancers (Aim 1)

  The proportion of participants with detected lung cancers will be determined by the frequency of image findings that indicate lung cancer, and an ultimate clinical diagnosis associated with the imaging finding.

  Up to 10 years

• Proportion of participants with detected other cancers (Aim 1)

  The proportion of participants with detected cancers, other than lung, will be determined by the frequency of image findings that indicate other cancer, and an ultimate clinical diagnosis associated with the imaging finding.

  Up to 10 years

• Proportion of participants with occupational lung disease (Aim 1)

  Occupational or work-related lung diseases are lung conditions that have been caused or made worse by long-term exposure to certain irritants in the workplace. The proportion of participants with occupational lung disease will be determined by the frequency of image findings that indicate occupationally associated lung disease, and an ultimate clinical diagnosis associated with the imaging finding.

  Up to 10 years

• Proportion of participants with diagnosed interstitial lung disease (Aim 1)

  Interstitial Lung Disease (ILD) is a group of diseases that irritate, inflame, or scar the lungs and supporting air sacs. The proportion of participants with diagnosed interstitial lung disease will be determined by the frequency of image findings that indicate ILD, and an ultimate clinical diagnosis associated with the imaging finding.

  Up to 10 years

• Number of participants within of each Lung-RADS risk group

  The Lung CT Screening Reporting and Data System (Lung-RADS) is a measure developed by the American College of Radiologists to standardize the reporting and management of screen-detected pulmonary nodules. Nodules are categorized as 0=Incomplete, 1=Negative, 2=Benign Appearance or Behavior, 3=Probably Benign, or 4A /4B /4X = Suspicious with an additional modifier of S=Other or C=Prior Lung Cancer to be added to the 4 category codes as needed. The frequency of participants within each Lung-RADS risk group as determined by imaging procedures will be reported.

  Up to 10 years

Secondary Outcomes (2)

• Percentage of participants with incidental clinical findings

  Up to 10 years

• Number of risk factors identified as associated with cancer development

  Up to 10 years

Study Arms (2)

Firefighters (Lung Screening CT)

OTHER

Participants will receive a single, low-dose, chest CT without contrast as indicated for lung cancer screening. Participants will be followed up for at least 1 year following the scan and have ongoing medical record reviews.

Procedure: Low-dose Computerized tomography (CT) of Chest; Other: Questionnaires; Other: Medical History

Firefighters with Previously Diagnosed Malignancy

OTHER

Participants with a history of cancer will have a medical record review as part of a case-control cohort.

Other: Medical History

Interventions

Medical History OTHER

Medical history will be obtained in person and via medical record review

Also known as: Medical Record Review, Medical Chart Review

Firefighters (Lung Screening CT); Firefighters with Previously Diagnosed Malignancy

Low-dose Computerized tomography (CT) of Chest PROCEDURE

Undergo CT for lung cancer screening

Also known as: Chest CT, Chest CT Scan, Low-dose Chest CT

Firefighters (Lung Screening CT)

Questionnaires OTHER

Participants will complete questionnaires on or before the day of the scan.

Firefighters (Lung Screening CT)

Eligibility Criteria

• Age: 35 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 35 years or greater. If the participant is above the age of 80, participants must be otherwise healthy and well-fit to undergo treatment if lung cancer were to be discovered.
• Never smoker or quit more than 15 years ago.
• Able to understand study procedures and to comply with them for the entire length of the study.
• Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it.
• Length in profession for 10 or more years. This includes both volunteer firefighting and professional firefighting, self-attested as verifiable by professional records.
• Additional cases for Aim 2:
• Age 18+, may include deceased firefighters.
• A previous or current history of confirmed thoracic malignancy (except localized skin cancer, cancer in situ, or other localized cancers)

You may not qualify if:

• Aim 1:
• Contraindication to any study-related procedure or assessment.
• Personal history of malignancy within 5 years (except localized skin cancer, cancer in situ, or localized cancers that are definitively treated and are unlikely to recur) or lung cancer at any time.
• Participants will be assessed for active pregnancy per standard procedure for clinical lung cancer screening CT at University of California, San Francisco which includes asking the participants directly along with documentation of whether the negative pregnancy was self-reported or confirmed with a urine pregnancy test.
• Prior CT chest within 1 year.
• Symptoms highly suggestive of lung cancer, including unexplained weight loss of over 30 pounds (lbs) within the past 12 months or unexplained hemoptysis.
• Aim 2:

Sponsors & Collaborators

• University of California, San Francisco: lead
• Hayward Firefighters Local 1909 of the International Association of Firefighters: collaborator

MeSH Terms

Conditions

Smoke Inhalation Injury; Respiratory Aspiration; Lung Diseases; Lung Neoplasms; Lung Diseases, Interstitial

Interventions

Surveys and Questionnaires; Health Records, Personal

Condition Hierarchy (Ancestors)

Burns, Inhalation; Burns; Wounds and Injuries; Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Medical Records; Records

Study Officials

• Jae Ho Sohn, MD, MS

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2025
• First Posted: February 20, 2025
• Study Start: March 31, 2026
• Primary Completion (Estimated): December 31, 2035
• Study Completion (Estimated): December 31, 2035
• Last Updated: April 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)