Opioid Prescribing in the Emergency Department for Sickle Cell Disease

NCT06835335 | Completed

• 1 other identifier: 25.02.01
• Study Type: observational
• Target: 1,063
• Locations: 2 countries
• Sites: 2

Brief Summary

This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.

Conditions

Sickle Cell Disease; Discrimination, Racial; Pain Management; Emergency Medicine

Outcome Measures

Primary Outcomes (1)

• Morphine prescription

  The proportion of patient for which physician would have prescribed morphine

  through study completion, an average of 1 year

Secondary Outcomes (3)

• Analgesic prescription between groups

  through study completion, an average of 1 year

• factors associated with differences in management between groups

  through study completion, an average of 1 year

• Differences according to patient and practitioner gender

  through study completion, an average of 1 year

Study Arms (4)

Non-black man

the case will present a non black man

Behavioral: opioid prescription

Black man

the case will present a non black man

Behavioral: opioid prescription

non-black woman

the case will present a non black woman

Behavioral: opioid prescription

black woman

the case will present a black woman

Behavioral: opioid prescription

Interventions

opioid prescription BEHAVIORAL

The intervention consisted of a randomized questionnaire presenting a clinical case of a patient suffering from severe abdominal pain. The control case was "As an emergency physician in an adult emergency department, you are presented with the following patient: The patient is a 39-year-old non-smoking male/female with a history of Meniere's disease and an allergy to Bactrim. He/she presents with abdominal pain that began abruptly 2 hours ago and has persisted despite taking NEFOPAM 45 minutes ago. This is his first episode. His/her vital signs are blood pressure 140/66, heart rate 91, pulse ox 97%, temperature 36.8°C. He/she rates his/her pain as 8/10 without any analgesic position. On clinical examination he/she presents with localized epigastric tenderness. The rest of the abdomen is soft, painless and depressed. There are hydro-aeriform noises. No diarrhea or vomiting. The rest of the clinical examination showed no abnormalities.". In the intervention case, patient had history of S

Black man; Non-black man; black woman; non-black woman

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population will consist in emergency medicine resident and physician, speaking French or English, in European countries. The population will be recruited with the use of professional networks and social medias

You may qualify if:

• Being a emergency physician

You may not qualify if:

• Working outside of Europe.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (2)

CHU de Nîmes

Nîmes, Occitanie, 30900, France

Location

Manchester University NHS FT

Manchester, Manchester, M139WL, United Kingdom

Location

Related Publications (1)

• Coisy F, Simon A, Occelli C, Dupriez F, Ageron FX, N'Diaye L, Feral-Pierssens AL, Yates G, Bobbia X. Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians. BMJ Open. 2025 Dec 24;15(12):e108836. doi: 10.1136/bmjopen-2025-108836.

  PMID: 41448706 RESULT

MeSH Terms

Conditions

Racism; Agnosia; Anemia, Sickle Cell

Condition Hierarchy (Ancestors)

Prejudice; Social Behavior; Behavior; Social Discrimination; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: February 19, 2025
• Study Start: February 17, 2025
• Primary Completion: March 19, 2025
• Study Completion: March 19, 2025
• Last Updated: January 23, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1); FR (1)