Intermittent Fasting vs. High-intensity Interval Training on the Lipid Profile of Obese Individuals.

NCT06834256 | Completed DMC

• 1 other identifier: P.T.REC/012/004625
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

we aimed to ascertain the effect of intermittent fasting (IF) vs. high-intensity interval training (HIIT) on the lipid profile and waist circumference (WC) of obese individuals.

Conditions

Obesity

Keywords

Intermittent Fasting,High-Intensity Training,,Obesity

Outcome Measures

Primary Outcomes (1)

• lipid profile

  A 5 mL fasting venous blood sample was collected following an eight-hour overnight fast, and LDL, HDL, TG, and TC levels were measured.

  lipid profile will be measured at baseline, and it will be measured again after six weeks

Secondary Outcomes (2)

• waist circumference

  waist circumference will be measured at baseline, and it will be measured again after six weeks

• The Framingham risk score (FRS)

  The Framingham risk score (FRS) will be measured at baseline, and it will be measured again after six weeks

Study Arms (2)

Group A (IF group)

EXPERIMENTAL

Group A followed the intermittent fasting( IF) regime ,with an intervention duration of six weeks for both groups

Behavioral: intermittent fasting

Group B performed High-intensity interval training( HIIT)

EXPERIMENTAL

High-intensity interval training performed on the treadmill three times weekly, with an intervention duration of six weeks for both groups

Behavioral: low volume high intensity interval training

Interventions

intermittent fasting BEHAVIORAL

Group A participants followed the IF diet for 6 weeks . intermittent fasting , specifically time-restricted feeding (TRF), involves consuming all of one's energy requirements inside an 8-h.The fasting interval was designated as 16 h, and the other 8-h was the eating period . During the 8-h eating window, the patient consumes a well-balanced meal consisting of 55%-65% carbs, 7%-20% protein, and 15%-30% fat .

Group A (IF group)

low volume high intensity interval training BEHAVIORAL

. Group B engaged in low-volume HIIT exercise (aerobic activity) three times weekly for six weeks. The exercise routine consisted of a 5-min warm-up phase at 70% of MHR, followed by four intervals of 2-min maximum effort cycling sessions (4 × 2 HIIT) compared to a sub-maximal workload at 85%-90% of MHR. The participants engaged in four work bouts, with each bout lasting around 4 min and followed by a 4-min rest period. During the workouts, the participants maintained an HR of 60%-70% of their MHR. This resulted in 8 min of intense physical activity during each training session. Additionally, there was a 5-min cooling down phase at 70% of the MHR. The treatment's intensity was adapted based on the modified Bruce protocol.

Group B performed High-intensity interval training( HIIT)

Eligibility Criteria

• Age: 35 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Egypt

Location

Related Publications (2)

• Nussbaumerova B, Rosolova H. Obesity and Dyslipidemia. Curr Atheroscler Rep. 2023 Dec;25(12):947-955. doi: 10.1007/s11883-023-01167-2. Epub 2023 Nov 18.

  PMID: 37979064 RESULT

• Nazari M, Minasian V, Hovsepian S. Effects of Two Types of Moderate- and High-Intensity Interval Training on Serum Salusin-alpha and Salusin-beta Levels and Lipid Profile in Women with Overweight/Obesity. Diabetes Metab Syndr Obes. 2020 Apr 24;13:1385-1390. doi: 10.2147/DMSO.S248476. eCollection 2020.

  PMID: 32425570 RESULT

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Heba Mousa, lecturer

  Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of physical therapy

Study Record Dates

• First Submitted: February 14, 2025
• First Posted: February 19, 2025
• Study Start: July 1, 2023
• Primary Completion: March 2, 2024
• Study Completion: May 1, 2024
• Last Updated: February 19, 2025

Record last verified: 2025-02

Locations

EG (1)