Incidence and Risk Factors for Post-Anesthetic Morphine Titration in Recovery Room After Hip and Knee Arthroplasties

NCT06832995 | Active Not Recruiting

• 1 other identifier: 2024-HPS
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the use of multimodal analgesia combining nerve block (NB) and systemic analgesia, intravenous (IV) morphine titration in the post-anesthetic care unit (PACU) after total hip (THA) and knee (TKA) arthroplasty is required to relieve early moderate-to-severe pain. Sedation occurrence during titration and a VAS score higher than 60/100mm are two independent risk factors for postoperative pain during hospitalization. The association of NB and multimodal analgesia constitutes the reference in evidence-based recommendations. An adductor or femoral triangle block, alone or associated with periarticular infiltration, is recommended during TKA. During THA, NB associated with surgical periarticular infiltration improves analgesia and rehabilitation This study aims to identify the incidence and risk factors of morphine titration in PACU after lower limb arthroplasty performed by 5 experienced surgeons and using a multimodal analgesic procedure

Conditions

Arthropathy of Hip; Arthropathy of Knee

Outcome Measures

Primary Outcomes (1)

• morphine titration

  after surgery, in the post-anesthetic care unit

Study Arms (2)

group T: IV morphine administered during the PACU stay

Drug: IV morphine administered during the PACU stay

group NT: no titration required in PACU

Interventions

IV morphine administered during the PACU stay DRUG

IV morphine administered during the PACU stay

group T: IV morphine administered during the PACU stay

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Each patient who underwent unilateral knee, total knee and total hip arthroplasty at the Sévigné Private Hospital between January 1, 2023, and December 31, 2023.

You may qualify if:

• Total hip arthroplasty
• Total Knee Arthroplasty
• Uni-compartmental knee arthroplasty (UKA)

You may not qualify if:

• Bilateral surgery Surgical revision Hip fracture surgery Other osteoarticular procedure(s) associated to hip/knee arthroplasty Refusal to use data Contra-indication of paracetamol, ketoprofen and dexamethasone

Sponsors & Collaborators

• Hôpital Privé Sévigné: lead

Study Sites (1)

Hôpital Privé Sévigné

Cesson-Sévigné, 35051, France

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2025
• First Posted: February 18, 2025
• Study Start: April 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: February 28, 2026
• Last Updated: February 18, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)