Atrial Strain in Septic Shock

NCT06832436 | Recruiting

• 1 other identifier: PI2025_843_0034
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.

Conditions

Septic Shock; Left Atrial Strain; Right Atrial Strain; Transthoracic Echocardiography; Speckle Tracking; Echocardiographic Software; Reproducibility; Critical Care

Keywords

transthoracic echocardiography; septic shock; left atrial strain; right atrial strain; speckle tracking; echocardiographic software; AutoStrain; Bland-Altman analysis; reproducibility; critical care

Outcome Measures

Primary Outcomes (1)

• variation of LASr between ECOPAC and UWS

  Agreement of LAS Reservoir Phase (LASr) measurement in manual mode between ECHOPAC and UWS

  1 year

Secondary Outcomes (20)

• variation of LAScd between ECHOPAC and UWS

  1 year

• variation of LASct between ECHOPAC and UWS

  1 year

• Comparison of LASr measurements in apical 2-chamber views

  1 year

• Comparison of LAScd measurements in apical 2-chamber views

  1 year

• Comparison of LASct measurements in apical 2-chamber views

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)

You may qualify if:

• Age: \>18 years
• Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
• TTE performed as part of medical management
• No objection to data usage

You may not qualify if:

• Pregnancy
• Moderate to severe valvular regurgitation/stenosis (\>grade 2)
• Ventricular or supraventricular tachyarrhythmia (HR \>140 bpm) at the time of TTE
• Poor echogenicity preventing LAS measurement
• Mechanical circulatory support
• Pacemaker dependence
• Patients under guardianship

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead
• Henri Mondor University Hospital: collaborator

Study Sites (1)

CHRU Amiens

Salouël, 80480, France

RECRUITING

MeSH Terms

Conditions

Shock, Septic

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Central Study Contacts

Christophe Beyls, MD

CONTACT

33+322087866; beyls.christophe@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 11, 2025
• First Posted: February 18, 2025
• Study Start: March 6, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: January 16, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)