NCT06829433

Brief Summary

This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and healthy individuals.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at P25-P50 for all trials

Timeline
4mo left

Started May 2024

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress86%
May 2024Sep 2026

Study Start

First participant enrolled

May 7, 2024

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

January 28, 2025

Completed
20 days until next milestone

First Posted

Study publicly available on registry

February 17, 2025

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2026

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Expected
Last Updated

February 21, 2025

Status Verified

February 1, 2025

Enrollment Period

1.7 years

First QC Date

January 28, 2025

Last Update Submit

February 19, 2025

Conditions

Knee OsteoarthritisTotal Knee Replacement

Outcome Measures

Primary Outcomes (1)

  • Peak knee adduction moment

    The external knee adduction moment (KAM), which reflects medial-to-lateral knee joint load distribution during gait, has become an OA treatment target. The peak KAM is a strong predictor of presence, severity, and the rate of progression of knee OA.

    From the start of a biomechanical movement testing visit to the end (approximately 2 hours)

Study Arms (3)

Total Knee Replacement

Other: No intervention

Knee Osteoarthritis

Other: No intervention

Asymptomatic Controls

Other: No intervention

Interventions

No interventionOTHER

Observational cross-sectional study

Asymptomatic ControlsKnee OsteoarthritisTotal Knee Replacement

Eligibility Criteria

Age40 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Local private physiotherapy clinics and local sports clubs

You may qualify if:

  • Diagnosed symptomatic bilateral or unilateral knee osteoarthritis, self-reported ability to walk without an aid for 10 minutes and to ascend and descend stairs, no neurological conditions or other musculoskeletal pathology/injury which would impact walking gait.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Psychology, Health and Sport Sciences, University of Portsmouth

Portsmouth, Hampshire, PO1 2ER, United Kingdom

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Central Study Contacts

Josie Morris, BSc

CONTACT

02392 846395josie.morris@port.ac.uk

Joseph Moore, PhD

CONTACT

joseph.moore@port.ac.uk

Study Design

Study Type
observational
Observational Model
CASE CROSSOVER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 28, 2025

First Posted

February 17, 2025

Study Start

May 7, 2024

Primary Completion

January 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

February 21, 2025

Record last verified: 2025-02

Locations

GB(1)