Dietary Wild Blueberries and Joint Health
Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
2 other identifiers
interventional
50
1 country
1
Brief Summary
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2025
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 10, 2025
CompletedFirst Posted
Study publicly available on registry
February 14, 2025
CompletedStudy Start
First participant enrolled
September 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2028
November 5, 2025
September 1, 2025
2.2 years
February 10, 2025
November 3, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Serum biomarkers of joint function
Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.
12 weeks
Secondary Outcomes (1)
Gut microbiome
12 weeks
Study Arms (2)
Wild blueberries
EXPERIMENTAL25g freeze-dried wild blueberries daily for 12 weeks
Placebo
PLACEBO COMPARATORPlacebo powder free from polyphenols matched for calories
Interventions
Eligibility Criteria
You may qualify if:
- Adults with documented multi-joint/knee arthritis
You may not qualify if:
- inability to give informed consent
- pregnancy or lactation
- planned knee replacement surgery
- allergy or contraindication to berries
- recent trauma of the knee responsible of the symptomatic knee
- intra-articular injection in the target knee/hip in the last 3 months
- oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
- use of berry extracts in the last 3 months
- special diets
- cancer treatment
- bone diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
OMRF
Oklahoma City, Oklahoma, 73104, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- OTHER
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
February 10, 2025
First Posted
February 14, 2025
Study Start
September 1, 2025
Primary Completion (Estimated)
December 1, 2027
Study Completion (Estimated)
March 1, 2028
Last Updated
November 5, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share