Comparison of Upper Extremity Functional Performance in Hemophilic and Healthy Children

NCT06826209 | Enrolling By Invitation

• 1 other identifier: FTREK24/103
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate the functional performance of the upper extremity joints (scapula, shoulder, elbow, and wrist) in haemophilic children and compare muscle strength and ADL limitations with healthy children.

Conditions

Hemophilia; Upper Extremity; Strength; Performance; Children

Keywords

Hemophilia; Muscle Strength; Upper Extremity

Outcome Measures

Primary Outcomes (1)

• Hemophilia Joint Health Score

  The Hemophilia Joint Health Score (HJHS) is a clinical tool used to assess joint health in individuals with hemophilia, focusing on major joints such as the knees, elbows, and ankles. It evaluates symptoms like pain, swelling, and range of motion restrictions, with a grading system that helps determine the severity of joint damage. The HJHS also considers joint function in daily activities, making it an essential tool for monitoring joint health and the progression of hemophilic arthropathy. It plays a vital role in both clinical management and research, helping guide treatment strategies and assess their effectiveness.

  Through study completion, an average of 1 year

Secondary Outcomes (1)

• Muscle Strength

  Through study completion, an average of 1 year

Study Arms (1)

Hemophilia groups

Patients group

Eligibility Criteria

• Age: 7 Years - 17 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Male children diagnosed with Hemophilia, who are being followed by the same physician at the Hematology Unit of the Department of Pediatrics, Faculty of Medicine, Hacettepe University, will be included in the study

You may qualify if:

• Diagnosed with Hemophilia A or B
• Receiving prophylaxis treatment (a routine treatment)
• Negative for inhibitors at the time of enrollment

You may not qualify if:

• Positive for inhibitors at the time of enrollment
• Acute elbow bleeding
• History of acute muscle bleeding
• History of surgery in any upper extremity joints
• Having undergone radionuclide synovectomy

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe Universit

Ankara, Ankara, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hemophilia A

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher

Study Record Dates

• First Submitted: February 6, 2025
• First Posted: February 13, 2025
• Study Start: October 24, 2024
• Primary Completion (Estimated): June 24, 2026
• Study Completion (Estimated): October 24, 2026
• Last Updated: February 13, 2025

Record last verified: 2025-02

Locations

TU (1)