NCT06821581|CompletedDMC
Economic-demographic Assessment of the Aseptic Mobilization of Knee Prostheses Through the RIPO Registry and Radiographic Analysis of the Case Series From the II Clinic of IOR
AL-TKA
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AL-TKA
Sponsor study identifier
observational
31
1 country
1
Study Start
January 13, 2026
Actual (reported)Primary Completion
May 7, 2026
Actual (reported)Study Completion
May 7, 2026
Actual (reported)The increase in life expectancy is leading to an increase in the average age of patients undergoing total knee arthroplasty (TKA), and, consequently, an increase in the number of revisions. The main cause of TKA failure is aseptic mobilization, which is described as the loss of integration between the prosthetic component and the bone in the absence of infection. This represents a significant impact on professional and economic resources for the Italian healthcare system. Aseptic mobilization can be caused by inadequate initial fixation of the implant and/or mechanical or biological loss of fixation over time, factors that often occur simultaneously. A careful, methodical evaluation of post-operative radiographs of TKAs remains an important diagnostic tool. The analysis of the causes of aseptic mobilization of TKAs and the associated economic impact in the Emilia Romagna region is useful for providing an estimate of the problem and identifying potential areas for improvement.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 7, 2026
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 6, 2025
Actual (reported)February 12, 2025
Actual (reported)January 13, 2026
Actual (reported)May 7, 2026
Actual (reported)May 7, 2026
Actual (reported)Demographic data
Collection of registry data related to the sample of patients undergoing TKA revision for aseptic mobilization, including demographic data
24 months
Healthcare expenses
24 months
Radiographic analysis
24 months
The analysis will be conducted on implants performed in the Emilia-Romagna region from 2003 to 2022 and on implants performed at the II Orthopedic and Traumatological Clinic of the Rizzoli Orthopedic Institute during the same period
IRCCS Istituto Ortopedico Rizzoli
Bologna, Bologna, 40136, Italy
31 participants (actual enrollment reported by the registry).
First Submitted
February 6, 2025
First Posted
February 12, 2025
Study Start
January 13, 2026
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
May 7, 2026
Actual (reported)Study Completion
May 7, 2026
Actual (reported)Last Updated
June 18, 2026
Record last verified: 2026-06
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Source: ClinicalTrials.gov.
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