Effects of Melatonin and Massage After Third Molar Surgery

NCT06812026 | Active Not Recruiting

• 1 other identifier: E.173684
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Lymphatic drainage massage is an important practice, especially for reducing edema. It is a very gentle, monotonous, slow, rhythmic massage applied to the skin surface. It accelerates the flow of lymph fluid and provides comfort by minimizing swelling. Lymphatic drainage massage, which is frequently used after impacted third molar surgery, helps reduce edema and increases patient comfort during the postoperative period. Melatonin, a hormone produced by the pineal gland, is a neurochemical substance that works in harmony with the body's natural rhythm. In addition to the brain, it is found in the retina, bone marrow, intestines, skin, and various blood cells. Conditions such as insomnia or jet lag may benefit from melatonin supplements. Besides contributing to sleep quality, melatonin may also assist in regulating the immune system, body temperature, blood pressure, and cortisol hormone levels.

Conditions

Melatonin

Keywords

edema; tooth removal; melatonin

Outcome Measures

Primary Outcomes (1)

• melatonin effect on edema: Postoperative edema will be measured preoperatively and on the 3rd and 7th days. Distances between the gonion-lateral canthus and tragus-labial commissure will be measured and recorded with a thread.

  during the post operative periods patients receive melatonin pill until 7 days

  postoperative 7 days

Secondary Outcomes (1)

• Lymphatic drainage massage effect on edema: Postoperative edema will be measured preoperatively and on the 3rd and 7th days. Distances between the gonion-lateral canthus and tragus-labial commissure will be measured and recorded with a thread.

  postoperative 7 days

Study Arms (3)

control

during the postoperative period receive any lymphatic drainage massage and melatonin

Other: no melatonin and massage

study melatonin

during the postoperative period receive only melatonin pills

Dietary Supplement: receive melatonin

study lymphatic drainage massage

during the postoperative period receive only lymphatic drainage massage

Other: receiving lymphatic drainage

Interventions

no melatonin and massage OTHER

receiving no melatonin and massage

control

receive melatonin DIETARY_SUPPLEMENT

receiving only melatıonin pills

study melatonin

receiving lymphatic drainage OTHER

receiving lymphatic drainage massage

study lymphatic drainage massage

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

who need impacted tooth removal surgery in the rutine clinic patients

You may qualify if:

• Patients need for removal surgery of impacted third molars.
• Patients without systemic diseases.

You may not qualify if:

• Presence of systemic diseases affecting general health.
• Presence of a malignant disease in the head and neck region.
• Patients with any bleeding disorders.
• Patients with cardiovascular diseases or those undergoing anticoagulant or antiplatelet therapy.

Sponsors & Collaborators

• Bezmialem Vakif University: lead

Study Sites (1)

Bezmialem Vakıf Universty

Istanbul, Fatih, 34093, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Edema

Interventions

Massage

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Therapy, Soft Tissue; Musculoskeletal Manipulations; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2025
• First Posted: February 6, 2025
• Study Start: January 1, 2025
• Primary Completion: May 1, 2026
• Study Completion (Estimated): May 10, 2026
• Last Updated: June 24, 2025

Record last verified: 2025-06

Locations

TU (1)