NCT06808919

Brief Summary

The mechanical characteristics play a crucial role in sustaining daily life activities and facilitating participation in sport activities and exercises demanding a diverse range of motion. Furthermore, it is postulated that the mechanical composition of the muscle could impact the minimal energy expenditure, perceived exertion, and risk of injury during physical activities. This study aims to examine the effects of various exercise approaches, including aerobic exercise, strength training, and whole-body vibration, on the passive mechanical properties of muscle tissue.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 10, 2020

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 15, 2021

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 5, 2022

Completed
3.1 years until next milestone

First Submitted

Initial submission to the registry

January 26, 2025

Completed
10 days until next milestone

First Posted

Study publicly available on registry

February 5, 2025

Completed
Last Updated

February 5, 2025

Status Verified

January 1, 2025

Enrollment Period

1.5 years

First QC Date

January 26, 2025

Last Update Submit

January 30, 2025

Conditions

Keywords

Stiffnessthicknesselastographyvibrationexercise

Outcome Measures

Primary Outcomes (4)

  • Muscle Strength

    Isokinetic testing and rehabilitation systems were utilized to assess muscle strength. An assessment was conducted on the concentric and eccentric forces exerted on the quadriceps femoris and hamstring muscles in the dominant lower extremity. The assessment of concentric strength was conducted within the knee flexion range of 0-90 degrees, while the evaluation of eccentric strength was undertaken in the knee flexion range of 10-90 degrees at a velocity of 60º/sec. The peak torque values acquired from the experiment were utilized as the basis for the analysis.

    Baseline and at Week 4

  • Horizontal Jump

    Test was conducted unilaterally on the dominant lower extremity. Horizontal jump was repeated three times and the average of the measurement results was recorded.

    Baseline and at Week 4

  • Muscle Stiffness

    Changes in muscle stiffness were evaluated through shear wave elastography. The alterations in the stiffness properties of the muscle were documented utilizing an ultrasound device. Measurements were conducted on the dominant lower extremity to evaluate alterations in the muscle stiffness of the quadriceps muscles (vastus medialis obliquus, rectus femoris) and hamstring muscles (biceps femoris, semimembranosus).

    Baseline and at Week 4

  • Muscle Thickness

    Changes in muscle thickness were evaluated through shear wave elastography. The alterations in the thickness properties of the muscle were documented utilizing an ultrasound device. Measurements were conducted on the dominant lower extremity to evaluate alterations in the muscle thickness of the quadriceps muscles (vastus medialis obliquus, rectus femoris) and hamstring muscles (biceps femoris, semimembranosus).

    Baseline and at Week 4

Study Arms (4)

Whole Body Vibration Exercise

EXPERIMENTAL

Whole body vibration exercises were conducted utilizing a specialized exercise platform. The participants underwent a prescribed exercise protocol involving both static and dynamic exercises on the designated platform. Specifically, static squats at a 30º angle, dynamic deep squats ranging from 30 to 60º, toe raises, weight transfer maneuvers during squats, as well as static and dynamic squat exercises performed unilaterally were implemented as part of the program. Each exercise was performed for 30-50 s with a frequency ranging from 30-45 Hz and an amplitude of 2 mm. The exercise regimen was structured to comprise three sets, with a designated three-minute inter-set rest interval. Physical exercise sessions were conducted on a weekly basis, with a duration ranging from 30 to 45 minutes. The intensity and duration of the exercises were progressively adjusted based on the adherence.

Other: Whole Body Vibration Exercise

Aerobic Exercise

EXPERIMENTAL

Aerobic exercise group were directed to engage in running activity on a conventional treadmill. The participants engaged in aerobic exercise, specifically moderate-to-high-intensity running at 65-80% of their maximal heart rate, for durations of 30-45 minutes per session, three times weekly. Heart rate was monitored with a portable pulse oximetry device.

Other: Aerobic Exercise

Strengthening Exercise

EXPERIMENTAL

Strengthening exercise group, participants engaged in various lower extremity strengthening activities such as straight leg raises, abduction and adduction movements, knee flexion-extension, ankle plantar-dorsiflexion exercises. These exercises were performed both on a bed and in standing positions, utilizing resistance exercise bands.

Other: Strengthening Exercise

Control Group

NO INTERVENTION

The participants continued their daily lives without any exercise practice until the end of the study.

Interventions

The participants underwent a prescribed exercise protocol involving both static and dynamic exercises on the designated platform. Specifically, static squats at a 30º angle, dynamic deep squats ranging from 30 to 60º, toe raises, weight transfer maneuvers during squats, as well as static and dynamic squat exercises performed unilaterally were implemented as part of the program

Also known as: WHole Body Vibration
Whole Body Vibration Exercise

The participants assigned to the aerobic exercise group were directed to engage in running activity on a conventional treadmill. The participants engaged in aerobic exercise, specifically moderate-to-high-intensity running at 65-80% of their maximal heart rate, for durations of 30-45 minutes per session, three times weekly. Heart rate was monitored with a portable pulse oximetry device.

Aerobic Exercise

Strengthening group, participants engaged in various lower extremity strengthening activities such as straight leg raises, abduction and adduction movements, knee flexion-extension, ankle plantar-dorsiflexion exercises. These exercises were performed both on a bed and in standing positions, utilizing resistance exercise bands.

Strengthening Exercise

Eligibility Criteria

Age18 Years - 40 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Physically healthy and able to engage in the exercise program without any impediments.
  • Voluntary participation

You may not qualify if:

  • Prior surgical interventions.
  • Neuromuscular or neurodegenerative disorders.
  • Heart failure.
  • Cardiac stents.
  • Pregnancy.
  • Participants who do not meet the above criteria, even if their current health status permits participation in exercise activities.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Bursa Uludag University

Bursa, Nilüfer, Turkey (Türkiye)

Location

Related Publications (2)

  • Uysal O, Delioglu K, Firat T. The effects of hamstring training methods on muscle viscoelastic properties in healthy young individuals. Scand J Med Sci Sports. 2021 Feb;31(2):371-379. doi: 10.1111/sms.13856. Epub 2020 Nov 3.

    PMID: 33084051BACKGROUND
  • Blazevich AJ. Adaptations in the passive mechanical properties of skeletal muscle to altered patterns of use. J Appl Physiol (1985). 2019 May 1;126(5):1483-1491. doi: 10.1152/japplphysiol.00700.2018. Epub 2018 Nov 9.

    PMID: 30412028BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor of Physical Therapy

Study Record Dates

First Submitted

January 26, 2025

First Posted

February 5, 2025

Study Start

February 10, 2020

Primary Completion

August 15, 2021

Study Completion

January 5, 2022

Last Updated

February 5, 2025

Record last verified: 2025-01

Locations