Investigation of Dual-Task Exercise's Effect in Parkinson's Disease

NCT06803212 | Completed

• 1 other identifier: 2024/109
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. One group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. Dual-task exercises were performed while conventional treatment was applied. The treatment program was applied as 60x5x6 min/day/week. Conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. Dual-task interventions included performing such as counting backward, word recall, and reading words backward. Assessments were repeated twice: Baseline and after a 30-session. "Demographic Information", "Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)", "Box and Block Test" and "Parkinson Disease Questionnaire (PDQ-39) were used as assessment tools.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (2)

• Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):

  The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.

  Baseline of the study

• Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):

  The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.

  End of the 30th physiotherapy session

Secondary Outcomes (5)

• Box Block Test (BBT)

  Baseline of the study

• Box Block Test (BBT)

  End of the 30th physiotherapy session

• Parkinson's Disease Questionnaire - 39 (PDQ-39)

  Baseline of the study

• Parkinson's Disease Questionnaire - 39 (PDQ-39)

  End of the 30th physiotherapy session

• Demographic Data Form

  Baseline of the study

Study Arms (2)

Conventional Therapy

ACTIVE COMPARATOR

This group were performed just conventional physiotherapy.

Other: Conventional Physiotherapy Program

Dual-Task Interference

EXPERIMENTAL

Dual-task exercises were applied during conventional physiotherapy practices.

Other: Conventional Physiotherapy Program; Other: Dual-Task Interference

Interventions

Conventional Physiotherapy Program OTHER

The patients' conventional physiotherapy program included stretching, strengthening, balance, and coordination exercises according to their individual needs

Conventional Therapy; Dual-Task Interference

Dual-Task Interference OTHER

This intervention consisted of counting backward, reading words backward, and remembering word exercises.

Dual-Task Interference

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 50-85 years with a diagnosis of Stage 1-3 Parkinson's disease, based on the Hoehn \& Yahr Scale
• Patients had to have no issues with performing basic mathematical operations, - A Mini-Mental State Examination (MMSE) score above 24 points,
• Regular medication use for at least 4 weeks (for patients who were prescribed medical treatment),
• No comorbid neurological, neuromuscular, or orthopedic diseases

You may not qualify if:

• Patients with vision or hearing impairments,
• Moderate-to-severe fluctuations in tremor or dyskinesia,
• Having deep brain stimulator implants, or sensory loss in the upper extremities.

Sponsors & Collaborators

• Emre Şenocak: lead

Study Sites (1)

İstanbul Tıp Merkezi

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor (PhD)

Study Record Dates

• First Submitted: January 27, 2025
• First Posted: January 31, 2025
• Study Start: June 28, 2024
• Primary Completion: December 30, 2024
• Study Completion: December 30, 2024
• Last Updated: January 31, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)