NCT06798532|Not Yet Recruiting
Interest of Preoperative Arteriography to Identify the Adamkiewicz Artery Before Surgery for Basi-thoracic Neuroblastic Tumors
AKA-NBL
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AKA-NBL
Sponsor study identifier
observational
150
1 country
27
Study Start
October 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Neuroblastic tumors (NBTs) develop from neural crest cells that give rise to the sympathetic nervous system. They include neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. They represent approximately 10% of solid tumors in children under 15 years of age. In 15 to 20% of cases, NBTs are located in the thoracic region. These paravertebral tumors have an extracanal component and some also have an intraspinal component (dumbbell tumors) that can cause spinal cord compression. Surgery for these tumors also exposes the patient to neurological complications. In the thorax, the basi-thoracic location (T9-T12) may be particularly at risk due to the presence of the artery of Adamkiewicz (AKA), which supplies blood to the spinal cord; damage to this artery can result in spinal cord ischemia. To avoid this scenario, some teams recommend performing spinal cord arteriography to identify AKA. However, many centers do not perform arteriography and do not report more postoperative complications. Currently, there is no consensus on the indications for performing preoperative spinal arteriography in patients undergoing surgery for basi-thoracic NBT. This study evaluates the practice in France of preoperative arteriography to identify the AKA among patients undergoing surgery for basi-thoracic neuroblastic tumors and analyzes the incidence of postoperative neurological complications in these patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 17, 2025
Actual (reported)January 29, 2025
Actual (reported)October 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Occurrence of neurological complications secondary to spinal cord ischemia
Assessment of postoperative neurological complications in patients undergoing surgery for basi-thoracic NBT, with or without preoperative spinal cord arteriography.
2005 to 2024
Demographic characteristics of patients undergoing surgery for basithoracic neuroblastic tumor
2005 to 2024
Outcome of patients undergoing surgery for basithoracic neuroblastic tumor
2005 to 2024
Patients undergoing surgery for a neuroblastic tumor (neuroblastoma, ganglioneuroblastoma) with basi-thoracic location between T8 and L1, with or without intraspinal component and treated in a pediatric surgery department in France between 2005 and 2024.
Collection of data from the patient's medical file.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients undergoing surgery for a neuroblastic tumor in a pediatric surgery department in France between 2005 and 2024 and meeting the inclusion criteria.
CHU d'Amiens
Amiens, 80000, France
CHU de Besançon
Besançon, 25000, France
CHU de Bordeaux
Bordeaux, 33000, France
Lindeire S, Hauser JM. Anatomy, Back, Artery of Adamkiewicz. 2025 Mar 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK532971/
Nordin AB, Fallon SC, Jea A, Kim ES. The use of spinal angiography in the management of posterior mediastinal tumors: case series and review of the literature. J Pediatr Surg. 2013 Sep;48(9):1871-7. doi: 10.1016/j.jpedsurg.2013.04.029.
Marianna MD Cornet
Assistance Publique - Hôpitaux de Paris
Sabine MD, PhD Sarnacki
Assistance Publique - Hôpitaux de Paris
First Submitted
January 17, 2025
First Posted
January 29, 2025
Study Start
October 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
April 2026
Estimated (date passed)Haemophilus Influenzae Pneumonia in Adults
Contact the study team to confirm eligibility.
CHU de Brest
Brest, 29200, France
CHU de Lyon
Bron, 69677, France
CHU de Caen
Caen, 14000, France
CHU de Dijon
Dijon, 21079, France
CHU de Grenoble
Grenoble, 38000, France
Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
CHU de Lille
Lille, 59000, France
CHU de Limoges
Limoges, 87000, France
CHU de Marseille
Marseille, 13005, France
CHU de Montpellier
Montpellier, 34090, France
CHU de Nancy
Nancy, 54100, France
CHU Nantes
Nantes, 44000, France
CHU Nice
Nice, 06200, France
Hôpital Trousseau
Paris, 75012, France
Hôpital Necker enfants malades
Paris, 75015, France
Hôpital Robert Debré
Paris, 75019, France
CHU de Poitiers
Poitiers, 86000, France
CHU de Reims
Reims, 51100, France
CHU de Rennes
Rennes, 35203 CEDEX 2, France
CHU de Rouen
Rouen, 76000, France
CHU de La Réunion
Saint-Denis, 97405, France
CHU de Strasbourg
Strasbourg, 671091, France
CHU de Toulouse
Toulouse, 31059 cedex 9, France
CHU de Tours
Tours, 37000, France
Schmidt A, Hempel JM, Ellerkamp V, Warmann SW, Ernemann U, Fuchs J. The Relevance of Preoperative Identification of the Adamkiewicz Artery in Posterior Mediastinal Pediatric Tumors. Ann Surg Oncol. 2022 Jan;29(1):493-499. doi: 10.1245/s10434-021-10381-8. Epub 2021 Jul 31.
Bosmia AN, Hogan E, Loukas M, Tubbs RS, Cohen-Gadol AA. Blood supply to the human spinal cord: part I. Anatomy and hemodynamics. Clin Anat. 2015 Jan;28(1):52-64. doi: 10.1002/ca.22281. Epub 2013 Jun 27.
De Bernardi B, Gambini C, Haupt R, Granata C, Rizzo A, Conte M, Tonini GP, Bianchi M, Giuliano M, Luksch R, Prete A, Viscardi E, Garaventa A, Sementa AR, Bruzzi P, Angelini P. Retrospective study of childhood ganglioneuroma. J Clin Oncol. 2008 Apr 1;26(10):1710-6. doi: 10.1200/JCO.2006.08.8799.
Furak J, Geczi T, Tiszlavicz L, Lazar G. Postoperative paraplegia after resection of a giant posterior mediastinal tumour. Importance of the blood supply in the upper spinal cord. Interact Cardiovasc Thorac Surg. 2011 May;12(5):855-6. doi: 10.1510/icvts.2010.257105. Epub 2011 Feb 8.
Boglino C, Martins AG, Ciprandi G, Sousinha M, Inserra A. Spinal cord vascular injuries following surgery of advanced thoracic neuroblastoma: an unusual catastrophic complication. Med Pediatr Oncol. 1999 May;32(5):349-52. doi: 10.1002/(sici)1096-911x(199905)32:53.0.co;2-p.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
September 12, 2025
Record last verified: 2025-09
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