Effect of Peng Block Application on Inflammation and Mortality in Hip Fractures

NCT06795724 | Completed

• 1 other identifier: E2-24-8891
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the investigators the effect of PENG block on SIRI (systemic inflammation response index) and 30-day mortality in geriatric patients(over 65 years old) undergoing hip surgery, and the effect on the length of hospital stay.

Conditions

Inflammatory Response; Anesthesia; Hip Fractures

Keywords

PENG block; inflammation; SIRI; Mortality; Hip fracture

Outcome Measures

Primary Outcomes (2)

• SIRI-systemic inflammatory response index

  The systemic inflammatory response index (SIRI) is defined as "neutrophil count × monocytes/lymphocyte counts".

  Preoperative, Postsurgery 4. 24. 48.hour

• IL-6

  Measurement of IL-6 level in blood

  Preoperative, Postsurgery 4. 24. 48.hour

Secondary Outcomes (7)

• CRP

  Preoperative, Postsurgery 4. 24. 48.hour

• SII

  Preoperative, Postsurgery 4. 24. 48.hour

• NLR

  Preoperative, Postsurgery 4. 24. 48.hour

• NRS score

  Postoperative 0-2-8-16-24-36-48 hour

• Additional analgesic requirement

  Postoperative first 24 hour

Study Arms (2)

PENG Block

ACTIVE COMPARATOR

PENG block will be performed before the surgery. For PENG block, patients are in the supine position is deposited. The convex ultrasound probe is initially placed over the anterior superior iliac spine, then the probe moves medially until the femoral artery is visualized. In this view, iliopectineal eminence (IPE), iliopsoas muscle and tendon, femoral artery and iliac muscle are observed. Between the psoas tendon and the IPE 22 gauge 80 mm block needle is guided and 20cc local anesthetic used in % 0.25 bupivacaine is administered by intermittent aspiration.

Other: PENG block

Control

OTHER

Standard analgesia method will be applied and analgesia will be provided with tramadol hydrochloride and paracetamol.

Other: Control

Interventions

PENG block OTHER

For PENG block, patients are in the supine position is deposited. The convex ultrasound probe is initially placed over the anterior superior iliac spine, then the probe moves medially until the femoral artery is visualized. In this view, iliopectineal eminence (IPE), iliopsoas muscle and tendon, femoral artery and iliac muscle are observed. Between the psoas tendon and the IPE 22 gauge 80 mm block needle is guided and 20cc local anesthetic used in % 0.25 bupivacaine is administered by intermittent aspiration.

PENG Block

Control OTHER

Standard analgesia method will be applied and analgesia will be provided with tramadol hydrochloride and paracetamol.

Control

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• ASA 1-2-3 score
• Hip Fracture Surgery

You may not qualify if:

• Refusal to participate in the study
• ASA score of 4 and above
• Obesity (BMI \>40)
• Failure of spinal block
• Switching to general anesthesia
• Patients undergoing revision surgery
• Patients with multitrauma
• Patients with old fractures (\>3 weeks)
• Patients receiving preoperative and intraoperative sedation
• Patients with active malignancy receiving RT, KT
• Patients with active infection, patients receiving antibiotic treatment
• Patients with contraindications for regional anesthesia techniques
• Patients receiving chronic treatment with steroids or immunosuppressants
• Patients using anti-inflammatory drugs

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (2)

• Fang Z, Gao B, Wang Z, Chen X, Liu M. Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study. Front Med (Lausanne). 2024 May 22;11:1401443. doi: 10.3389/fmed.2024.1401443. eCollection 2024.

  PMID: 38841577 BACKGROUND

• Gentili ME, Mazoit JX, Samii K K, Fletcher D. The effect of a sciatic nerve block on the development of inflammation in carrageenan injected rats. Anesth Analg. 1999 Oct;89(4):979-84. doi: 10.1097/00000539-199910000-00029.

  PMID: 10512275 BACKGROUND

MeSH Terms

Conditions

Hip Fractures; Inflammation

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• burak nalbant

  Ankara City Hospital Bilkent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: January 16, 2025
• First Posted: January 28, 2025
• Study Start: January 30, 2025
• Primary Completion: July 17, 2025
• Study Completion: August 17, 2025
• Last Updated: November 17, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)