Post Operative Sensitivity of MTA Obturation

NCT06795282 | Completed FDA Drug

• 1 other identifier: AAvci
• Study Type: observational
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the difference in postoperative pain caused by different root canal sealers in patients with irreversible pulpitis symptoms and no apical lesions.

Conditions

Endodontically Treated Teeth; Dental Pulp Disease; Endodontic Disease

Keywords

MTA; Post-op pain; Epoxy resin sealer; putty MTA

Outcome Measures

Primary Outcomes (1)

• 7-day postoperative pain after root canal treatment

  At the end of the visit, patients were educated to record their postoperative pain level by assigning a number between 0 and 10 using the numerical rating scale (NRS) chart. They were categorized into four: 0=no pain, 1-3=mild pain, 4-6=moderate pain, and 7-10=severe pain. The patients were asked to record their pain level preoperatively, at 6, 12, and 24 h, and daily for up to 7 days, and return it to he investigators at a specific time.

  7 days

Study Arms (3)

powder-liquid MTA

The root canal will be filled with MTA at the end of the first session and patients will fill out a post-op pain form for 1 week.

Drug: MTA

Putty MTA

The root canal will be filled with putty MTA at the end of the first session and patients will fill out a post-op pain form for 1 week.

Drug: MTA

Epoxy resin sealer

The root canal will be filled with epoxy resin sealer and gutta-percha at the end of the first session and patients will fill out a post-op pain form for 1 week.

Interventions

MTA DRUG

MTA is primarily composed of tricalcium silicate, dicalcium silicate, bismuth oxide (for radiopacity), and small amounts of calcium sulfate. MTA is highly biocompatible, making it suitable for use in the root canal system and areas in close contact with tissues.

Putty MTA; powder-liquid MTA

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Systemically healthy patients between the ages of 18-65

You may qualify if:

• asymptomatic tooth with delayed positive response to thermal tests and electric pulp tests
• large pulp perforation during caries removal,
• inflamed pulp in which bleeding could not be controlled within 5 min,
• periodontally healthy mature mandibular first or second molar tooth.

You may not qualify if:

• patients if they were diabetic, immunocompromised, pregnant,
• had a positive history of antibiotic use during the past 1 month,
• required antibiotic prophylaxis
• used analgesic within 7 days prior to the beginning of treatment,
• were allergic to the materials used during root canal treatment,
• if the bleeding could be controlled within 5 min and vital pulp treatment could be performed,
• the tooth had negative response to vitality tests and/or was symptomatic,
• had an associated periapical lesion visible on a radiograph,
• needed a post-core or was planned to serve as prosthetic support,
• had a calcified root canal and internal or external root resorption,
• had tooth with open apex
• mandibular third molars

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes University Faculty of Dentistry

Kayseri, 38000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Dental Pulp Diseases; Tooth, Nonvital; Pain, Postoperative

Interventions

Pemetrexed

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Guanine; Hypoxanthines; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 22, 2024
• First Posted: January 28, 2025
• Study Start: January 30, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 15, 2025
• Last Updated: January 2, 2026

Record last verified: 2025-12

Locations

TU (1)