Induction Therapy of PTX+BV Followed by Atezolizumab+Nab-PTX for PD-L1+ TNBC

NCT06793553 | Recruiting Phase 2 DMC

• 1 other identifier: JBCRG-M10
• Study Type: interventional
• Target: 106
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this research is to evaluate the efficacy of the treatment strategy to administer atezolizumab + nab-paclitaxel (PTX) following 2 cycles of induction therapy with PTX + bevacizumab (induction treatment strategy) in programmed cell death ligand-1 (PD-L1)-positive metastatic triple-negative breast cancer (mTNBC) in comparison with the standard atezolizumab + nab-PTX therapy.

Conditions

Metastatic Breast Cancer

Keywords

PD-L1-positive; bevacizumab; induction therapy; immunotherapy

Outcome Measures

Primary Outcomes (1)

• Progression-free survival (PFS) *

  Whether the PFS is prolonged with statistical significance (level of significance, one-sided 10%) in the induction therapy group compared to the standard treatment group will be evaluated. \* In this research, all antitumor effects will be assessed based on the evaluation by the primary physician.

  2 years

Secondary Outcomes (1)

• (1) 2-year PFS rate (2) 2-year PFS rate in patients with non-PD on the first imaging assessment in the induction therapy group

  2 years

Study Arms (2)

Induction therapy group

ACTIVE COMPARATOR

2 cycles of PTX + bevacizumab → atezolizumab + nab-PTX

Drug: Induction therapy

Control group (standard treatment group)

EXPERIMENTAL

Atezolizumab + nab-PTX

Drug: Induction therapy

Interventions

Induction therapy DRUG

2 cycles of PTX+ bevacizumab induction therapy followed by atezolizumab+nab-PTX

Control group (standard treatment group); Induction therapy group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with metastatic recurrent or unresectable advanced TNBC
• Documented PD-L1 positivity (SP142 IC ≥ 1) confirmed by local assessment of the most recent tumor sample or an archival tumor sample.
• In the case of patients who were candidates for curative treatment, the duration from the completion of the curative treatment {date of surgery for primary breast cancer or date of last dose of peri-operative drug therapy (including anthracycline regimen, taxane regimen, anti-PD-(L)1 antibody, capecitabine, poly ADP-ribose polimerase \[PARP\] inhibitors, etc.), whichever is later} to the first local or distant recurrence should be at least 6 months. The date of postoperative radiotherapy is not included in this calculation. The use of anti-PD-(L)1 antibodies is allowed during perioperative drug therapy.
• ECOG PS 0-1
• Female or male aged 18 years or older.
• Histologically or cytologically confirmed TNBC that is ER-negative (\< 10% positive cell occupancy or Allred Proportion score of 0-2), HER2-negative (IHC 1+ or less or FISH/DISH negative) according to ASCO/CAP Criteria 2018 (in the case of IHC2+, negativity is confirmed by FISH/DISH).
• Patients who have not received chemotherapy for metastatic recurrent or unresectable advanced cancer. However, prior treatment with PARP inhibitors for metastatic recurrent or unresectable advanced cancers in patients with pathogenic BRCA variants is allowed.
• Having measurable or non-measurable lesions as assessed by local CT or MRI. Tumor lesions located at a previously irradiated site will be considered evaluable if unequivocal progression is seen after radiation.
• Laboratory tests performed within 14 days before enrollment meet the following criteria \[1\] to \[8\]. However, patients must not have received granulocyte colony-stimulating factor (G-CSF) or blood transfusion within 14 days prior to the date of blood sampling.
• \[1\] Neutrophil count ≥ 1500/mm3 \[2\] Platelet count ≥ 10 x 104/mm3 \[3\] Hemoglobin ≥ 8.0 g/dL \[4\] AST (GOT) ≤ 100 IU/L (≤ 200 IU/L if liver metastasis is present) \[5\] ALT (GPT) ≤ 100 IU/L(≤ 200 IU/L if liver metastasis is present) \[6\] Total bilirubin ≤ 1.5 mg/dL Total bilirubin \< 3.0 mg/dL for patients with Gilbert's syndrome \[7\] Creatinine ≤ 1.5 mg/dL \[8\] Any of the following criteria is met: i) Urine protein (dipstick) is negative (-) or 1+ ii) If urine protein (dipstick) is ≥ 2+; Measurement of 24-hour urine protein shows urine protein ≤ 1 g/24 hours (may be substituted by urine protein/creatinine ratio ≤ 1)
• (10) Blood pressure is sufficiently controlled (systolic blood pressure ≤ 150 mmHg and diastolic blood pressure ≤ 90 mmHg with ≤ 2 antihypertensive drugs \[counted as the number of combinations\]).
• (11) Patients expected to survive for at least 3 months.
• (12) Written consent has been obtained from the patient himself/herself after sufficient explanation of the contents of the study before registration.
• (13) In the case of female patients of childbearing potential (including patients who have no menstruation for medical reasons such as chemical menopause), the patients must agree to continue to practice contraception until 5 months after the last dose of atezolizumab or 6 months after the last dose of bevacizumab, nab-PTX or PTX, whichever comes later. Patients must also agree not to breastfeed during study treatment and for at least 5 months after the last dose of atezolizumab and at least 6 months after the last dose of bevacizumab. In the case of male patients with a partner of childbearing potential, the patient whose partner must agree to continue to practice contraception until 6 months after the last administration of PTX and nab-PTX.

You may not qualify if:

• Having active brain metastases or carcinomatous meningitis. Previously treated brain metastases are allowed if neurological symptoms have returned to baseline and are clinically stable for at least 2 weeks prior to enrollment.
• Patients with a history of invasive malignancy within 3 years prior to enrollment. However, basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or lesions equivalent to carcinoma in situ or intramucosal carcinoma that are assessed as cured by local treatment are not included in active double cancer.
• Concurrent or metachronous bilateral invasive breast cancer. However, the patients will be accepted if bilateral lesions are TNBC and are confirmed to be PD-L1-positive by evaluation using a sample of a recurrent lesion.
• Patients who have received radiotherapy within 14 days prior to enrollment. (Administration or irradiation on the same day of the week 14 days prior to the day of enrollment is permitted.)
• Patients who have received other study drugs within 14 days prior to enrollment. (Administration on the same day of the week 14 days prior to the day of enrollment is permitted.)
• Administration of a live vaccine within 30 days of the first dose of the study drug. Administration of inactivated vaccines is permitted.
• Patients who have received systemic corticosteroid or immunosuppressant equivalent to prednisone exceeding 10 mg/day within 14 days prior to enrollment for active autoimmune disease. (excluding temporary administration for examination or prophylactic administration)
• Active infection requiring systemic treatment.
• Patients who concurrently have interstitial lung disease/pneumonitis at the time of enrollment or who have a history of interstitial lung disease/pneumonitis requiring systemic corticosteroids administration. (A history of radiation pneumonitis \[fibrosis\] within the radiation field is permitted.)
• Patients who are pregnant, possibly pregnant, or lactating.
• Patients who are positive for HBs antigen or HCV antibody. Patients positive for HCV antibody whose HCV virus level is below the detection limit will be permitted.
• Patients who are positive for HIV-1 antibody or HIV-2 antibody (test is not essential for enrollment).
• Patients with significant cardiovascular disease. Patients with a history of myocardial infarction, acute coronary artery disease, coronary angioplasty/stenting/bypass grafting within the last 6 months. Patients with congestive heart failure of Class III to IV of the New York Heart Association.
• Patients with the following history/concomitant diseases:
• \[1\] Poorly controlled diabetes mellitus \[2\] Grade ≥ 2 peripheral sensory neuropathy \[3\] Congenital haemorrhagic diathesis/coagulopathy \[4\] Arterial thromboembolism (cerebral infarction, etc.) or venous thromboembolism (deep vein thrombosis, pulmonary embolism, etc.) within 6 months prior to enrollment \[5\] Gastrointestinal perforation, active gastrointestinal ulcer, and Grade ≥ 3 haemorrhage (site not specified) \[6\] Other serious complications (renal failure, hepatic failure, etc.)

Sponsors & Collaborators

• Japan Breast Cancer Research Group: lead
• Chugai Pharmaceutical: collaborator

Study Sites (1)

Yukinori Ozaki

Koto-ku, 3-8-31, Tokyo, 135-8550, Japan

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Neoadjuvant Therapy

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Combined Modality Therapy; Therapeutics

Central Study Contacts

Yukinori Ozaki

CONTACT

+81-3-3520-0111; yukinori.ozaki@jfcr.or.jp

Norikazu Masuda

CONTACT

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2025
• First Posted: January 27, 2025
• Study Start: September 13, 2024
• Primary Completion: March 31, 2026
• Study Completion (Estimated): September 30, 2028
• Last Updated: January 30, 2025

Record last verified: 2025-01

Locations

JP (1)