Walking Training Improves Thyroid and Cardiometabolic Markers in Postmenopausal Obesity

NCT06793345 | Completed DMC

• 1 other identifier: Training and thyroid function
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is: Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors. Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.

Conditions

Thyroid Hormones; Cardiometabolic Risk Factors

Keywords

Thyroid hormones; Lipid profile; Obesity; Blood pressure; Moderate intensity intermittent walking training; Body composition

Outcome Measures

Primary Outcomes (3)

• Thyroid hormones

  Serum thyroid hormone concentrations are measured from a blood sample (5 ml) obtained from a prominent superficial vein in the antecubital region.

  At baseline and after ten weeks of MIWT.

• Body composition

  Body composition was assessed using an electronic scale (Tanita BC-533, Tokyo, Japan),

  At baseline and after ten weeks of MIWT.

• Lipid profile

  Measured by blood samples (5ml) from a prominent superficial vein in the antecubital region.

  At baseline and after ten weeks of MIWT.

Secondary Outcomes (4)

• Systolic and diastolic blood pressure

  At baseline and after ten weeks of MIWT.

• Heart rate

  At baseline and after ten weeks of MIWT

• 6 min walking test distance

  At baseline and after ten weeks of MIWT

• Perceived exertion rating

  At baseline and after ten weeks of MIWT.

Study Arms (2)

MIWT group

EXPERIMENTAL

The MIWT group received moderate intensity intermittent walking training four times per week for 10 weeks.

Other: Moderate intensity intermittent walking training

Control group

NO INTERVENTION

The control group received no intervention for 10 weeks.

Interventions

Moderate intensity intermittent walking training OTHER

The intensity of the training is 60 to 80% of 6MWTdistance.

MIWT group

Eligibility Criteria

• Age: 50 Years - 60 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index≥ 30 kg.m-2.
• Age between 50 and 60.
• Amenorrhea for \>12 months.
• Stable eating habits.

You may not qualify if:

• Chronic diseases.
• Medical contraindications to physical activity.
• Hormone replacement therapy.

Sponsors & Collaborators

• Wissal Abassi: lead

Study Sites (1)

High Institute of Sports and Physical Education of Kef

Boulifa, Kef Governorate, 7100, Tunisia

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 18, 2025
• First Posted: January 27, 2025
• Study Start: September 23, 2024
• Primary Completion: December 22, 2024
• Study Completion: December 22, 2024
• Last Updated: January 27, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)