Effects of Anesthesia on Atelectasis

NCT06790901 | Completed

• 1 other identifier: 2023/16-6
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

We know that respiratory functions of patients are affected under general anaesthesia. Although there are many underlying causes of ventilation-perfusion mismatch in the airways, the main cause is atelectasis during general anaesthesia. Atelectasis occurs in almost all patients receiving general anaesthesia. The main cause of atelectasis is the loss of muscle tone during general anaesthesia. Postoperative atelectasis was described in the last century. It is defined as the closure of the alveoli due to a decrease in inspiratory force and collapse of the lung and the resulting loss of aeration. Inhalation anaesthetics have been shown to cause hypoxic pulmonary vasoconstriction in studies. However, not all inhalation anaesthetics affect the airways in the same way. In patients who will undergo surgical procedures under different general anaesthesia maintenance methods, conditions that disrupt the ventilation-perfusion balance in the lung peroperatively can be diagnosed and monitored early, easily and inexpensively by lung ultrasonography. Lung ultrasound is a noninvasive, reliable, reliable, radiation-free imaging method that provides instantaneous imaging at the bedside. Lung ultrasound score is a scoring system that provides scoring of the loss of ventilation in the lung. For this purpose, it was aimed to divide both lung tissues into 12 areas and to give a score between 0 and 3 points and to show the severity of the loss of aeration according to the resulting total score.

Conditions

Atelectasis; General Aneshesia

Keywords

Lung Ultrasound Score; general anesthesia; Atelectasis; Inhalation agents

Outcome Measures

Primary Outcomes (1)

• Peroperative Atelectasis

  from induction to postoperative 1st hour

Study Arms (3)

Group Total IV anesthesia

Procedure: LUNG ULTRASOUND

Group Sevoflurane

Procedure: LUNG ULTRASOUND

Group Desflurane

Procedure: LUNG ULTRASOUND

Interventions

LUNG ULTRASOUND PROCEDURE

Determination of atelectsis By Lung Ultrasound Score

Group Desflurane; Group Sevoflurane; Group Total IV anesthesia

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

18-65 years old, ASA I-II, who will undergo rhinoplasty, septorhinoplasty operation

You may qualify if:

• years old ASA I-II Surgical procedure time between 2 hours and 5 hours in supine position Patients who will undergo rhinoplasty, septorhinoplasty operation Patients whose consent was obtained with an informed consent form

You may not qualify if:

• Those with a history of malignant hyperthermia,
• People with alcohol or drug addiction,
• Presence of dementia or confusion,
• Uncooperative patients,
• Those with respiratory disease,
• Those with coronary artery disease, congestive heart failure,
• Patients with unstable blood pressure,
• Significant anaemia, liver or kidney disease,
• Women during pregnancy or lactation,
• Allergy to anaesthetic agents,
• Body mass index (BMI) \>30 kg/m2,
• Those with sepsis or bacterial infection, Body temperature below 35°C and above 38°C at control value

Sponsors & Collaborators

• Zonguldak Bulent Ecevit University: lead

Study Sites (1)

Zonguladk Bulent ecevit University

Zonguldak, Kozlu, 67600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Atelectasis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: January 13, 2025
• First Posted: January 24, 2025
• Study Start: September 15, 2023
• Primary Completion: August 30, 2024
• Study Completion: January 12, 2025
• Last Updated: January 24, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)