Comparison of Thread Technique Versus Aspiration Plus Steroid Injection for Wrist Ganglion Recurrence

NCT06790615 | Completed Phase 1

• 1 other identifier: ERC/19/15(b)
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a randomized controlled trial comparing two treatment methods for wrist ganglion cysts to evaluate which method has a lower recurrence rate. Ganglion cysts are non-cancerous lumps commonly found on the wrist, arising from joint capsules or tendon sheaths. They are often painless but may cause discomfort or cosmetic concerns. The primary objective of this study was to compare the recurrence rates of wrist ganglia treated with two methods: Thread technique: Inserting a silk thread through the cyst to allow drainage. Aspiration plus steroid injection: Removing the cyst fluid with a needle followed by injecting a corticosteroid to reduce inflammation. Study Design The trial was conducted at HIT Hospital, Taxila, from June to December 2020. It included 60 participants aged 18-50 years, divided equally into two groups. Group A underwent the thread technique, and Group B received aspiration and steroid injections. Patients were followed up at intervals of 2 weeks, 6 weeks, 3 months, and 6 months to monitor for cyst recurrence. Methods Thread Technique: A silk suture was passed through the cyst, allowing its contents to drain. Patients were instructed to massage the area daily for one week. The thread was removed once drainage ceased. Aspiration and Steroid Injection: Fluid was removed using a needle, and 40 mg of methylprednisolone acetate was injected into the cyst cavity. Both procedures were performed under local anesthesia in an outpatient setting.

Conditions

Ganglion Cyst

Keywords

Cyst; ganglion; Thread technique; Wrist swelling

Outcome Measures

Primary Outcomes (4)

• Recurrence

  Number of patients with recurrence of ganglion cyst

  2 weeks

• Recurrence

  Number of patients with recurrence of ganglion cyst

  6 weeks

• Recurrence

  Number of patients with recurrence of ganglion cyst

  3 months

• Recurrence

  Number of patients with recurrence of ganglion cyst

  6 months

Study Arms (2)

Thread technique

EXPERIMENTAL

The thread technique was used for the wrist ganglion

Other: Silk suture

Steriod injection

ACTIVE COMPARATOR

Steriod injection was given into the cyst after aspiration

Drug: methyl prednisolone acetate

Interventions

methyl prednisolone acetate DRUG

methyl prednisolone acetate was injected after the aspiration

Steriod injection

Silk suture OTHER

The silk suture was used for threading technique

Thread technique

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with a clinical and radiological diagnosis of wrist ganglion.
• Both genders.
• Age range of 18 to 50 years.

You may not qualify if:

• Patients with a history of previous invasive treatments.
• Patients with compound ganglion.
• Patients with diabetes mellitus.
• Patients with bleeding diathesis. Patients with immunosuppression. Patients with rheumatoid arthritis.

Sponsors & Collaborators

• Benazir Bhutto Hospital, Rawalpindi: lead

Study Sites (1)

PAF Hospital, Islamabad

Islamabad, Federal, Pakistan

Location

MeSH Terms

Conditions

Ganglion Cysts; Cysts

Condition Hierarchy (Ancestors)

Neoplasms; Mucinoses; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Abdul Basit, MBBS, FCPS

  POF Hospital, Wah Cantt.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Surgeon

Model Details: Randomized controlled trial

Study Record Dates

• First Submitted: January 14, 2025
• First Posted: January 24, 2025
• Study Start: June 1, 2020
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: January 24, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)