Hemoglobin-to-red Blood Cell Distribution Width Ratio and Hypothermia for Elderly Patient

NCT06790017 | Completed

• 1 other identifier: AESH-EK1-2024-0082
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

As individuals age, they often enter a phase of increased "frailty." Elderly and frail patients represent a population that requires heightened sensitivity and close monitoring during surgical procedures. This study aims to investigate the relationship between the Hemoglobin-to-Red Blood Cell Distribution Width (Hb/RDW) ratio and perioperative hypothermia in elderly patients undergoing transurethral prostatectomy. This is an observational study. Preoperative blood test results and intraoperative body temperature measurements of the patients will be recorded in our data forms.

Conditions

Transurethral Resection of Prostate Syndrome; Elderly (People Aged 65 or More); General Anesthetic

Keywords

elderly; hypothermia

Outcome Measures

Primary Outcomes (1)

• Perioperative Hypothermia

  Perioperative hypothermia is defined as any core temperature less than 96.8°F (36.0°C)

  1 hour before anesthesia and intraoperative

Secondary Outcomes (2)

• Frailty

  preoperative

• Red blood cell distribution width

  1 hour before anesthesia and intraoperative

Study Arms (2)

Low hemoglobin to red cell distribution width ratio (HRR)

Patients whose HRR rate is below 9.97 and are considered frail

Other: body temperature

High hemoglobin to red cell distribution width ratio (HRR)

Patients whose HRR ratio is above 9.97 and are considered non-frail

Other: body temperature

Interventions

body temperature OTHER

Body temperature measurement will be performed in the preoperative and intraoperative periods.

High hemoglobin to red cell distribution width ratio (HRR); Low hemoglobin to red cell distribution width ratio (HRR)

Eligibility Criteria

• Age: 65 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Etlik City Hospital, Urology Operating Rooms

You may qualify if:

• Patients who provided informed consent.
• Patients scheduled for transurethral prostatectomy surgery.
• Patients classified as ASA-PS 1, 2, or 3.
• Male patients aged 65 years or older.
• Patients undergoing elective surgery.
• Patients receiving general anesthesia.

You may not qualify if:

• Patients who did not provide informed consent.
• Patients undergoing emergency surgery.
• Patients with conditions that disrupt thermoregulation (e.g., intracranial mass, peripheral vascular diseases, sepsis).
• Patients with a body temperature of \<34℃ or \>38℃ upon arrival at the preoperative waiting room.
• Patients who used heating methods other than the routine cotton cover in the preoperative waiting room.
• Patients who received additional heating methods other than the routinely applied intraoperative hot air blower drapes.
• Patients undergoing surgery under any type of anesthesia other than general anesthesia.
• Patients who were taken out of the operating room while intubated.

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Etlik City Hospital

Ankara, 06170, Turkey (Türkiye)

Location

Related Publications (2)

• Zhu M, Wei C, Yang X, Huang Y, Xu Y, Xiong Z. Lower haemoglobin-to-red blood cell distribution width ratio is independently associated with frailty in community-dwelling older adults: a cross-sectional study. BMJ Open. 2023 Jul 9;13(7):e069141. doi: 10.1136/bmjopen-2022-069141.

  PMID: 37423632 BACKGROUND

• Qu J, Zhou T, Xue M, Sun H, Shen Y, Chen Y, Tang L, Qian L, You J, Yang R, Liu Y. Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease. Front Cardiovasc Med. 2021 Aug 27;8:728800. doi: 10.3389/fcvm.2021.728800. eCollection 2021.

  PMID: 34513961 BACKGROUND

MeSH Terms

Conditions

Hypothermia

Interventions

Body Temperature

Condition Hierarchy (Ancestors)

Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Vital Signs; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Physiological Phenomena

Study Officials

• Gokcen KULTUROGLU

  Ankara Etlik City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: January 9, 2025
• First Posted: January 23, 2025
• Study Start: April 9, 2025
• Primary Completion: June 1, 2025
• Study Completion: June 11, 2025
• Last Updated: June 12, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)