Hydrogen-Infused Water for Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life

NCT06788015 | Completed

• 1 other identifier: THIC-1-24
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Participants are randomized into intervention and control groups, with outcomes measured over a specified period. The findings aim to elucidate whether hydrogen-infused water water provides significant benefits for physical performance, hydration status, and overall well-being compared to standard hydration methods.

Conditions

Exercise Overtraining

Keywords

endurance

Outcome Measures

Primary Outcomes (1)

• Time to exhaustion

  Running time to exhaustion at treadmill

  Change from baseline time to exhaustion at 4 weeks

Secondary Outcomes (1)

• Total body water

  Change from baseline total body water at 4 weeks

Other Outcomes (1)

• 36-Item Short Form Health Survey

  Change from baseline 36-Item Short Form Health Survey total score at 4 weeks

Study Arms (2)

Hydrogen-infused water

EXPERIMENTAL

One can of hydrogen-infused water consumed before breakfast and dinner

Dietary Supplement: Hydrogen-infused water

Placebo

PLACEBO COMPARATOR

One can of hydrogen-free water consumed before breakfast and dinner

Dietary Supplement: Placebo

Interventions

Hydrogen-infused water DIETARY_SUPPLEMENT

Water containing molecular hydrogen

Hydrogen-infused water

Placebo DIETARY_SUPPLEMENT

Water containing no molecular hydrogen

Placebo

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18.0 - 29.9 years
• Body mass index 18.5 - 24.9 kg/m2
• Collegiate athletes with training experience \>3 years
• Weekly exercise \> 5 hours
• Given written informed consent

You may not qualify if:

• Major chronic diseases or acute disorders
• History of dietary supplement usage in the 4 weeks preceding the study initiation
• Unwillingness to return for a follow-up
• Participation in other clinical trials

Sponsors & Collaborators

• University of Novi Sad, Faculty of Sport and Physical Education: lead

Study Sites (1)

FSPE Applied BIoenergetics Lab

Novi Sad, Vojvodina, 21000, Serbia

Location

Related Publications (1)

• Ostojic SM. Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities. Curr Pharm Des. 2021;27(5):723-730. doi: 10.2174/1381612826666200922155242.

  PMID: 32962610 BACKGROUND

MeSH Terms

Conditions

Overtraining Syndrome

Condition Hierarchy (Ancestors)

Fatigue; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 16, 2025
• First Posted: January 22, 2025
• Study Start: November 15, 2024
• Primary Completion: February 28, 2025
• Study Completion: April 15, 2025
• Last Updated: December 22, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR

Locations

SE (1)