NCT06295016

Brief Summary

Purpose: Investigating the effects of stressors and recovery regulation on the super-compensation effect of high-intensity intensive training (IT) in endurance athletes. Methods: This study will recruit 176 competitively trained endurance adult athletes. Participants will conduct a 7-week 3-stage experiment, including 3 weeks of regular training, 3 weeks of 130% progressive IT, and 1 week of 55% taper. Measurement will include training responses (performance and fatigue symptoms), stressors, recovery regulation, and mood state at baseline, during and after regular training, IT, and taper separately. According to the performance after taper, all participants will category into either the responder or non-responder of well-response to supercompensation effect. Statistic analysis: Independent t-test, Chi-squared test, and binary logistic regression will be used to compare the difference in training responses, stressors, recovery regulation, and mood state characteristics between responder and non-responder groups. P value sets at 0.15 for identifying the potential predictors. Logistic stepwise multiple regression will be used further to determine the significant predictors for the responders of well-response to the super-compensation among endurance athletes. P value sets at 0.05.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
158

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2023

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

November 20, 2023

Completed
4 months until next milestone

First Posted

Study publicly available on registry

March 6, 2024

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2024

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2025

Completed
Last Updated

March 6, 2024

Status Verified

November 1, 2023

Enrollment Period

1 year

First QC Date

November 20, 2023

Last Update Submit

March 4, 2024

Conditions

Keywords

SupercompensationHigh-intensity intensive trainingStressorRecovery regulation

Outcome Measures

Primary Outcomes (4)

  • Stressor

    The stress score of the recovery-stress questionnaire for athletes (RESTQ-sport) questionnaire.

    Pre-test and the following 7 weeks (follow up once a week)

  • Recovery regulation

    The recovery score of the recovery-stress questionnaire for athletes (RESTQ-sport) questionnaire.

    Pre-test and the following 7 weeks (follow up once a week)

  • Mood state

    The total score of the Profile of Mood State (POMS) questionnaire.

    Pre-test and the following 7 weeks (follow up once a week)

  • Peak power output

    The peak power output at the end of an incremental exercise test.

    Baseline, the 3rd, 4th, 6th and 7th week

Secondary Outcomes (2)

  • Maximal heart rate

    Baseline, the 3rd, 4th, 6th and 7th week

  • Fatigue state

    Pre-test and the following 7 weeks (follow up once a week)

Study Arms (3)

Regular training

NO INTERVENTION

Participants maintain their regular training habits for 3 weeks.

High-intensity intensive training

EXPERIMENTAL

Participants increase their regular regular training volume by 10% each week for 3 weeks.

Other: High-intensity intensive training

Taper

EXPERIMENTAL

Participants gradually reduced to 55% of their regular training volume for 1 week.

Other: Taper

Interventions

Participants will conduct a 3-weeks of 130% progressive high-intensity intensive training (increasing by 10% each week). Week 1: Increase training to 110% of participants' regular training volume. Week 2: Increase training to 120% of participants' regular training volume. Week 3: Increase training to 130% of participants' regular training volume.

High-intensity intensive training
TaperOTHER

Participants will conduct a 1-week taper phase by gradually reducing to 55% of their regular training volume. Day 1: Decrease current training volume by 20%. Day 2: Decrease current training volume by 15%. Day 3: Decrease current training volume by 10%. Day 4: Decrease current training volume by 10%. Day 5: Decrease current training volume by 10%. Day 6: Decrease current training volume by 5%. Day 7: Decrease current training volume by 5%.

Taper

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Athletes aged 18 or above with endurance-type competitive sports experience. For instance, athletes who have participated in track events of 400 meters or longer, marathons, road cycling, swimming, rowing, race walking, triathlons, orienteering, and similar competitive events.
  • A habitual training regimen of at least 6 hours per week. For instance, training three times a week for at least 2 hours each session.
  • Minimum of 3 years of training experience, such as being part of a school team or a specialized athlete.
  • No severe injuries within the past year. For instance, severe non-regenerative anemia, craniotomy due to cerebral aneurysm, acute myocardial infarction, severe hepatic cirrhosis, severe systemic lupus erythematosus nephritis, severe rheumatoid arthritis, severe head trauma, and similar conditions.
  • Not taking substances affecting athletic, physiological, and psychological performance. For instance, unauthorized drugs, prohibited substances, growth hormones like somatotropin and related substances, β2 agonists, hormone and metabolic modulators, diuretics, masking agents, stimulants, anesthetics, cannabis, adrenal corticosteroids, and similar substances.

You may not qualify if:

  • Presence of an illness resembling symptoms of overtraining syndrome in the week before the start of the experiment. This includes primary viral illnesses, bacterial infections, associated inflammatory diseases, diabetes, or hyperthyroidism.
  • Suspected symptoms of high-risk overtraining syndrome in the week preceding the experiment, such as persistent fatigue or exhaustion, unexplained significant decrease in athletic performance exceeding 10%.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University

Taipei, 112304, Taiwan

RECRUITING

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MeSH Terms

Conditions

Overtraining SyndromeStress, Psychological

Condition Hierarchy (Ancestors)

FatigueSigns and SymptomsPathological Conditions, Signs and SymptomsBehavioral SymptomsBehavior

Study Officials

  • Mei-Wun Tsai

    Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Prior to the commencement of the experiment and during the experimental period, both the participants and the investigator will be unaware of whether the participants exhibit a good response to compensatory training effects. After the participants complete the entire experimental procedure, they will be grouped post hoc based on their outcomes following the intervention, according to predetermined criteria. The criteria for determining whether there is a good response to compensatory training effects: 1. Non-response group: Exercise performance during the tapering period (week 7) shows a significant increase compared to post-intervention (week 6) and is higher than pre-intervention (week 3) exercise performance. 2. Response group: Exercise performance during the tapering period (week 7) shows a significant increase compared to post-intervention (week 6) and is higher than the change in exercise performance during normal training (= week 3 - week 1).
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Model Details: The present study is designed as a prospective intervention and prognostic prediction study, employing a single-subject design with a reversal (ABA) design. This design involves a self-controlled intervention experiment with three phases: baseline training period (A), high-intensity, high-volume training period (B), and reduced training period (A). Subsequently, the study aims to explore predictive factors influencing the presence or absence of favorable compensatory training effects following the intervention.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 20, 2023

First Posted

March 6, 2024

Study Start

September 1, 2023

Primary Completion

August 31, 2024

Study Completion

August 31, 2025

Last Updated

March 6, 2024

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will not share

Locations