Communication Strategies to Increase HPV Vaccination Intention
A Cluster Randomized Controlled Trial Testing Communication Strategies to Increase HPV Vaccination Intention: A Survey Experiment
1 other identifier
interventional
5,337
1 country
1
Brief Summary
This research aims to identify communication strategies to improve the uptake of vaccines using an experimental design, focusing on the Human Papillomavirus (HPV) vaccine, which is highly effective in preventing HPV-related cancers. However, low HPV vaccination rates among adults remain a significant public health challenge. Although randomized controlled trials (RCTs) have demonstrated that interventions can increase vaccine uptake in children, few RCTs have been conducted on adults. To address this gap, a multidisciplinary investigative team with expertise in communication, medicine, nursing, and behavior-change intervention research, and a history of extensive collaboration, will conduct a survey experiment on a national sample of over 3,689 adults to identify the most promising theory-based messages to strengthen HPV vaccine intentions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2025
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 12, 2024
CompletedFirst Posted
Study publicly available on registry
January 20, 2025
CompletedStudy Start
First participant enrolled
February 6, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 15, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2025
CompletedMarch 30, 2026
March 1, 2026
2 months
December 12, 2024
March 24, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Intention to Vaccinate
Validated 3-item likert scale assessing HPV vaccination intention.
Immediately after the intervention
Study Arms (6)
Theory-Based Message Condition 1
EXPERIMENTALTheory-Based Message Condition 2
EXPERIMENTALTheory-Based Message Condition 3
EXPERIMENTALTheory-Based Message Condition 4
EXPERIMENTALTheory-Based Message Condition 5
EXPERIMENTALTheory-Based Message Condition 6
ACTIVE COMPARATORInterventions
We will randomly assign participants in equal numbers to one of five theory-based HPV vaccine message conditions or an attention-matched control arm.
Eligibility Criteria
You may qualify if:
- years old
You may not qualify if:
- Under 18 and over 45 years old
- Received HPV vaccine or unsure about receipt
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
December 12, 2024
First Posted
January 20, 2025
Study Start
February 6, 2025
Primary Completion
April 15, 2025
Study Completion
May 1, 2025
Last Updated
March 30, 2026
Record last verified: 2026-03