Comparison Between Positive and Negative sUPP

NCT06783699 | Completed

• 1 other identifier: 202406048RINC
• Study Type: observational
• Target: 481
• Locations: 1 country
• Sites: 1

Brief Summary

Urodynamic stress incontinence is a prevalent condition among women, characterized by involuntary urine leakage during activities that increase intra-abdominal pressure, such as coughing, sneezing, or physical exertion. Stress urethral pressure profile measurement is an important diagnostic tool used during urodynamic studies to assess urethral function. In some women with urodynamic stress incontinence, involuntary urine leakage occurs during this measurement, yet the clinical and urodynamic significance of this leakage remains unclear. This study aims to elucidate the differences in clinical and urodynamic findings between women with urodynamic stress incontinence who experience involuntary urine leakage during stress urethral pressure profile measurement and those who do not. Between July 2009 and December 2023, a total of 481 women with urodynamic stress incontinence were included and divided into positive and negative sUPP groups. The medical records, including urodynamic study, 3-day bladder dairy and questionnaires regarding lower urinary tract symptoms were reviewed.

Conditions

Urodynamic Stress Incontinence

Keywords

Urodynamic stress incontinence

Outcome Measures

Primary Outcomes (1)

• Urinary incontinence in bladder diary

  Subjective urinary incontinence described in bladder diary

  Between July 2009 and December 2023

Secondary Outcomes (1)

• Pad weight

  Between July 2009 and December 2023

Study Arms (2)

Positive sUPP

Involuntary urine leak during cough stress test in urethral pressure profile

Negative sUPP

No urine leak during cough stress test in urethral pressure profile

Eligibility Criteria

• Age: 20 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women aged more than 20-year-old with lower urinary tract symptoms underwent urodynamic study and were diagnosed with urodynamic stress incontinence.

You may qualify if:

• \>20 y/o
• Women with lower urinary tract symptoms
• Received urodynamic stress incontinence and was diagnosed with urodynamic stress incontinence

You may not qualify if:

• Women who are pregnant
• With chronic pelvic inflammatory disease

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Related Publications (5)

• Wu PC, Hsiao SM, Lin HH. Prevalence and predictors of nocturnal polyuria in females with overactive bladder syndrome. World J Urol. 2022 Feb;40(2):519-527. doi: 10.1007/s00345-021-03865-5. Epub 2021 Nov 11.

  PMID: 34762173 RESULT

• Hsiao SM, Wu PC, Chang TC, Chen CH, Lin HH. Urodynamic and Bladder Diary Factors Predict Overactive Bladder-wet in Women: A Comparison With Overactive Bladder-dry. Int Neurourol J. 2019 Mar;23(1):69-74. doi: 10.5213/inj.1836212.106. Epub 2019 Mar 31.

  PMID: 30943696 RESULT

• Hsiao SM, Hsiao CF, Chen CH, Chang TC, Wu WY, Lin HH. Evaluation of bladder diary parameters based on correlation with the volume at strong desire to void in filling cystometry. PLoS One. 2013 Jul 29;8(7):e69946. doi: 10.1371/journal.pone.0069946. Print 2013.

  PMID: 23922866 RESULT

• Rosier PFWM, Schaefer W, Lose G, Goldman HB, Guralnick M, Eustice S, Dickinson T, Hashim H. International Continence Society Good Urodynamic Practices and Terms 2016: Urodynamics, uroflowmetry, cystometry, and pressure-flow study. Neurourol Urodyn. 2017 Jun;36(5):1243-1260. doi: 10.1002/nau.23124. Epub 2016 Dec 5.

  PMID: 27917521 RESULT

• Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN; International Urogynecological Association; International Continence Society. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn. 2010;29(1):4-20. doi: 10.1002/nau.20798.

  PMID: 19941278 RESULT

Study Officials

• Ho-Hsiung Lin, M.D. Ph.D

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 14, 2025
• First Posted: January 20, 2025
• Study Start: June 28, 2024
• Primary Completion: July 31, 2024
• Study Completion: August 31, 2024
• Last Updated: January 20, 2025

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)