Development of an Ensemble Learning-based, Multi-dimensional Sensory Impairment Score to Predict Cognitive Impairment in an Elderly Cohort of Southern Italy

NCT06783010 | Not Yet Recruiting DMC

• 2 other identifiers: ASLBari_DEMETRAPNRR-MAD-2022-12376656
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

There is now strong scientific literature showing a relationship between sensory loss and cognitive performance and between sensory loss and incident dementia. We take as our starting point that people with hearing, vision, and/or cognitive problems have poorer health outcomes, possibly due to due to common age-related mechanism(s), iatrogenic problems in the health care system (e.g., misdiagnosis), and/or the decay of social networks. With this evidence, our project will provide a better understanding of the relationship between sensory loss and cognitive loss in older adults with or at risk for dementia using objective technologies to measure sensory deficits that refer not only to vision loss, hearing loss, olfaction and taste but also to senses deemed atypical, i.e., nociception. In particular, the project aims:

1. 1.To assess the specific association between different sensory measures (central and peripheral hearing loss, retinal abnormalities measured by OCT, smell and taste objective measures, chronic pain, and proprioception subjective and electrophysiological measures.
2. 2.To develop a multi-dimensional score using sensory features and clinical and lifestyle variables to predict the different types of dementia (Alzheimer's Disease, Fronto-Temporal Dementia, and Vascular Dementia) at different stages (Mild Cognitive impairment and Normal Cognition).
3. 3.To create a connectomic map of the MRI morphologic and dynamic features of the Dementia cases and their relationships with sensorial features, describing the patterns differences in respect to the normal cognition controls.

Conditions

Sensory Impairments; Cognitive Impairment; Artificial Intelligence

Keywords

artificial intelligence; sensory impairments; cognitive impairments

Outcome Measures

Primary Outcomes (1)

• cognitive decline

  every subject from MOCA 15.5-26 to a MOCA score lower than 15.5

  36 months

Study Arms (4)

controls

normal hearing and cognitive

case_1

only with cognitive impairment (MOCA lower than 17.5)

case_2

subjects with a central auditory processing disorder and cognitive impairment (MOCA lower than 17.5)

case_3

subjects with a central auditory processing disorder diagnosis

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

older adults (over 65 years of age)

Sponsors & Collaborators

• Azienda Sanitaria Locale Bari: lead
• Istituti Clinici Scientifici Maugeri SpA: collaborator
• IRCCS De Bellis, Castellana: collaborator

Related Publications (8)

• Sardone R, Castellana F, Bortone I, Lampignano L, Zupo R, Lozupone M, Griseta C, Dibello V, Seripa D, Guerra V, Donghia R, Logroscino G, Solfrizzi V, Quaranta N, Ferrucci L, Giannelli G, Panza F. Association Between Central and Peripheral Age-Related Hearing Loss and Different Frailty Phenotypes in an Older Population in Southern Italy. JAMA Otolaryngol Head Neck Surg. 2021 Jun 1;147(6):561-571. doi: 10.1001/jamaoto.2020.5334.

  PMID: 33570584 RESULT

• Sardone R, Battista P, Donghia R, Lozupone M, Tortelli R, Guerra V, Grasso A, Griseta C, Castellana F, Zupo R, Lampignano L, Sborgia G, Capozzo R, Bortone I, Stallone R, Fiorella ML, Passantino A, Giannelli G, Seripa D, Panza F, Logroscino G, Quaranta N. Age-Related Central Auditory Processing Disorder, MCI, and Dementia in an Older Population of Southern Italy. Otolaryngol Head Neck Surg. 2020 Aug;163(2):348-355. doi: 10.1177/0194599820913635. Epub 2020 Apr 21.

  PMID: 32312167 RESULT

• Panza F, Lozupone M, Sardone R, Battista P, Piccininni M, Dibello V, La Montagna M, Stallone R, Venezia P, Liguori A, Giannelli G, Bellomo A, Greco A, Daniele A, Seripa D, Quaranta N, Logroscino G. Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life. Ther Adv Chronic Dis. 2018 Nov 9;10:2040622318811000. doi: 10.1177/2040622318811000. eCollection 2019.

  PMID: 31452865 RESULT

• Nadar MS, Jasem Z, Manee FS. The Cognitive Functions in Adults with Chronic Pain: A Comparative Study. Pain Res Manag. 2016;2016:5719380. doi: 10.1155/2016/5719380. Epub 2016 Dec 29.

  PMID: 28127233 RESULT

• Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimaki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbaek G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-446. doi: 10.1016/S0140-6736(20)30367-6. Epub 2020 Jul 30. No abstract available.

  PMID: 32738937 RESULT

• Gates GA, Gibbons LE, McCurry SM, Crane PK, Feeney MP, Larson EB. Executive dysfunction and presbycusis in older persons with and without memory loss and dementia. Cogn Behav Neurol. 2010 Dec;23(4):218-23. doi: 10.1097/WNN.0b013e3181d748d7.

  PMID: 21150347 RESULT

• Gadkaree SK, Sun DQ, Li C, Lin FR, Ferrucci L, Simonsick EM, Agrawal Y. Does Sensory Function Decline Independently or Concomitantly with Age? Data from the Baltimore Longitudinal Study of Aging. J Aging Res. 2016;2016:1865038. doi: 10.1155/2016/1865038. Epub 2016 Sep 27.

  PMID: 27774319 RESULT

• Brenowitz WD, Kaup AR, Yaffe K. Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores. Alzheimers Dement. 2020 Oct;16(10):1384-1392. doi: 10.1002/alz.12134. Epub 2020 Jul 12.

  PMID: 32657033 RESULT

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Francesco Panza, MD

CONTACT

3282954840; f_panza@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: January 14, 2025
• First Posted: January 20, 2025
• Study Start: June 30, 2025
• Primary Completion: June 30, 2025
• Study Completion: January 10, 2026
• Last Updated: January 20, 2025

Record last verified: 2025-01