Clinical Profile of Skin Aging Based on Dermoscopy Photoaging Scale and Glogau Scale - Study of Leucocyte Telomere Length, Biomarker P16, and Body Mass Index

NCT06779032 | Not Yet Recruiting DMC

• 1 other identifier: LTLP16
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

To determine the relationship between clinical appearance, dermoscopic examination results of photoaging profiles based on clinical examination, DPAS score and leucocyte telomere length, to analyze the relationship between BMI, waist circumference, triglycerides, and cellular senescence biomarker p16 levels with a population experiencing skin aging and having Fitzpatrick III-V skin types. The questions which is aim to be answered are:

1. 1.What is the photoaging profile based on clinical examination results in skin aging cases?
2. 2.What is the photoaging profile based on DPAS scores in skin aging cases?
3. 3.What is the leucocyte telomere length profile in skin aging cases?
4. 4.What is the relationship between leucocyte telomere length and clinical examination in skin aging cases?
5. 5.What is the relationship between leucocyte telomere length and DPAS degree in skin aging cases?
6. 6.What is the profile of cellular senescence p16 biomarker levels in a population that has experienced clinical skin aging with Fitzpatrick III-V skin types?
7. 7.What is the skin aging profile based on the Glogau and DPAS scales in a population with Fitzpatrick III-V skin types?
8. 8.Is there a relationship between the results of the cellular senescence p16 biomarker examination and clinical skin aging assessed based on the Glogau and DPAS scales in a population with Fitzpatrick III-V skin types?
9. 9.Is there a relationship between the results of BMI, waist circumference, and triglyceride examinations with clinical skin aging assessed using the Glogau and DPAS scales with Fitzpatrick III-V skin types?

Conditions

Aging Skin; Body Mass Index; Cellular Senescence; Triglycerides; Waist Circumference

Keywords

skin aging; body mass index; triglycerides; waist circumference; cellular senescene; p16

Outcome Measures

Primary Outcomes (6)

• profile of leucocyte telomere length

  profile of leucocyte telomere length in skin aging

  1 year

• profile of skin examination with dermoscopic photoaging scale (DPAS)

  skin aging is assessed from dermoscopic photoaging scale on dermoscopic images, looking at pigmentary changes, vascular changes, telangiectasis, wrinkles, actinic keratoses, and blackheads. There are four facial regions assessed in the DPAS score calculation, namely the forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44. The greater the score, the higher marks of skin aging

  1 year

• Profile of body mass index

  checking BMI to see if there is correlation so skin aging

  1 year

• profile of p16

  checking p16 as a cellular senescence to skin aging

  1 year

• profile of waist circumference

  Waist circumferemce will be checked, to see if there is correlation with skin aging

  1 year

• profile triglycerides

  triglycerides will be checked, to see if there is correlation with skin aging

  1 year

Study Arms (2)

leucocyte telomere length (LTL)

patients will be assessed LTL to see if there is correlation with body mass index, triglycerides, and skin aging

Diagnostic Test: blood draw

p16

patients will be assessed p16 to see if there is correlation with body mass index, triglycerides, and skin aging

Diagnostic Test: blood draw

Interventions

blood draw DIAGNOSTIC_TEST

PCR method to see leucocyte telomere length

leucocyte telomere length (LTL); p16

Eligibility Criteria

• Age: 31 Years - 61 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

people with age from 31- 61 years

You may qualify if:

• female aged 31-61 years
• healthy
• willing to participate in the study

You may not qualify if:

• history of diseases (heart, kidney, liver)
• pregnant or breastfeeding patientes

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

Universitas Indonesia

Jakarta, DKI Jakarta, 10430, Indonesia

Location

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Irma Bernadette Sitohang, Prof IBSS Bernadette Sitohang, Proffesor

CONTACT

+62818130761; irma_bernadette@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. dr. Irma Bernadette S. Sitohang, Sp.DVE, Subsp. D.K.E

Study Record Dates

• First Submitted: December 22, 2024
• First Posted: January 16, 2025
• Study Start: February 5, 2025
• Primary Completion: May 20, 2025
• Study Completion: August 20, 2025
• Last Updated: January 16, 2025

Record last verified: 2024-12

Locations

ID (1)