BC008-1A Injection for Recurrent CNS WHO G4 Glioma

NCT06773481 | Recruiting Phase 1

• 1 other identifier: BC0081A-103
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this Phase I clinical study is to evaluate the safety, preliminary efficacy and pharmacokinetic characteristics of BC008-1A injection in subjects with recurrent CNS WHO grade 4 glioma. This is a randomized and open-label study, with two dose groups set up, and 10 to 20 subjects will be enrolled in each group.

Conditions

Glioma; Glioma Tumor Recurrence; Glioma, Recurrent High Grade; Glioblastomas (GBM); Glioblastoma WHO Grade IV

Keywords

glioma; PD-1; TIGIT; bispecific antibody; glioblastoma

Outcome Measures

Primary Outcomes (1)

• Safety

  Assesing the type, frequency, severity, and duration of adverse events.

  Up to 2 years

Secondary Outcomes (11)

• objective response rate (ORR)

  Up to 2 years

• Maximum Plasma Concentration (Cmax)

  3 months

• Immunogenicity

  Up to 2 years

• Karnofsky performance score(KPS)

  Up to 2 years

• Recommended phase II dose

  Up to 2 years

Study Arms (2)

BC008-1A 900mg

EXPERIMENTAL

Biological: BC008-1A

BC008-1A 1200mg

EXPERIMENTAL

Biological: BC008-1A

Interventions

BC008-1A BIOLOGICAL

Biological: 900 mg BC008-1A will be intravenously injected once every 3 weeks.

BC008-1A 900mg

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Voluntarily sign the informed consent form;
• Recurrent CNS WHO grade 4 glioma: Subjects with CNS WHO grade 4 glioma confirmed by histopathology, who have experienced disease progression as diagnosed by MRI and evaluated by RANO criteria after standard treatment and have no surgical plan;
• Male or female aged ≥ 18 years old;
• Expected survival time ≥ 12 weeks;
• According to the RANO criteria, there is at least one measurable intracranial tumor lesion;
• KPS ≥ 70;
• Have sufficient hematological function, liver function and renal function, and meet the following laboratory test results before enrollment (withoutusing any cell growth factors, platelet and red blood cell transfusion or other blood transfusion treatments within 1 week before the first dose of study treatment):
• Basically normal liver function: Total bilirubin (TBIL) ≤ 1.5 × ULN (patients with known Gilbert disease with serum bilirubin level ≤3 × ULN can be included), alanine aminotransferase (ALT) ≤ 2.5 × ULN, aspartate aminotransferase (AST) ≤ 2.5 × ULN, alkaline phosphatase ≤ 2.5 × ULN;
• Basically normal renal function: Creatinine (Cr) ≤ 1.5 × ULN, or estimated glomerular filtration rate (eGFR) ≥ 30 mL/min;
• Basically normal coagulation function: International normalized ratio (INR) ≤ 1.5 × ULN, prothrombin time (PT) ≤ 1.5 × ULN, activated partial thromboplastin time (APTT) ≤ 1.5 × ULN (for subjects receiving anticoagulant treatment, the investigator judges that INR, PT and APTT are within the safe and effective treatment range and there is no clinical condition of active bleeding or increased bleeding risk);
• Basically normal hematological system: Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L (without granulocyte colony-stimulating factor treatment), platelet (PLT) ≥ 100 × 10\^9/L, hemoglobin (Hb) ≥ 90 g/L, white blood cell count ≥ 2.0 × 10\^9/L, lymphocyte count ≥ 0.5 ×10\^9/L.
• Female subjects of childbearing age or male subjects whose partners are women of childbearing age need to agree to take effective contraceptive measures during the trial period (from signing the ICF to 6 months after the last dose).

You may not qualify if:

• Having been previously exposed to any anti-TIGIT, PD-1, PD-L1 or CTLA-4 drugs;
• Having suffered from other malignant tumors and currently requiring treatment (except for cervical carcinoma in situ, basal cell carcinoma or squamous cell carcinoma of the skin that have been adequately treated);
• Having an autoimmune disease or a history of autoimmune diseases or related symptoms;
• Subjects who cannot undergo MRI (such as those with a pacemaker implanted, non-removable metal dentures, claustrophobia, etc.);
• Subjects who have received chemotherapy (those who have used nitrosourea drugs within 42 days before the first receipt of the experimental drug cannot be enrolled), radiotherapy, biotherapy, endocrine therapy, targeted therapy, tumor-treating fields therapy, immunotherapy or other anti-tumor treatments such as anti-tumor Chinese patent medicines within 28 days before the first use of the study drug or within 5 half-lives of the drug (whichever is shorter), or subjects who have received any clinical study treatment and the interval from the first use of the study drug is ≤ 28 days;
• Subjects with tumor lesions involving the brainstem, spinal cord or leptomeningeal dissemination and metastasis;
• Those who have used corticosteroids within 1 month before participating in the trial and have received systemic treatment with a daily dose higher than 3 mg of dexamethasone or an equivalent dose of other hormones;
• The toxicity caused by previous anti-tumor treatments has not decreased to ≤ grade 1 as defined in CTCAE version 5.0 (except for toxicities judged by the investigator to have no safety risks, such as alopecia, grade 2 peripheral neurotoxicity, hypothyroidism stabilized by hormone replacement therapy, etc.);
• Those who have received live attenuated vaccines within 4 weeks before the first administration of the study drug or plan to receive them during the study period;
• Subjects with active infections at present (such as acute bacterial infections, tuberculosis, pulmonary infections, etc.);
• Those who are positive for hepatitis B core antibody (HBcAb) or hepatitis B surface antigen (HBsAg), and whose HBV DNA is higher than the upper limit of the normal value of the site, or those judged by doctors to have active hepatitis, hepatitis C virus (HCV) infection, or those who are positive for human immunodeficiency virus (HIV) antibody, or those who are positive for Treponema pallidum antibody (Tp-Ab);
• Those with cardiac clinical symptoms or diseases that are not well controlled, such as uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg), unstable angina pectoris or myocardial infarction occurring within 6 months before enrollment in the trial, or poorly controlled arrhythmias (including QTc interval ≥ 450 ms for men and ≥ 470 ms for women, with the QTc interval calculated by the Fridericia formula), etc.;
• Cardiac function classified as grade III or IV according to the New York Heart Association (NYHA) classification;
• Those who are allergic to the components or excipients of the experimental drug, antibody drugs or any other therapeutic proteins (such as fresh frozen plasma, human serum albumin, cytokines or interleukins, etc.), or those with a history of severe allergies and suspected to have severe allergic reactions (NCI-CTCAEv5.0 ≥ grade 3);
• Those with a clear history of neurological or mental disorders in the past, such as dementia, and with poor compliance;

Sponsors & Collaborators

• Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd.: lead
• Beijing Tiantan Hospital: collaborator

Study Sites (1)

Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

RECRUITING

MeSH Terms

Conditions

Glioma; Glioblastoma

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Astrocytoma

Central Study Contacts

Jianing Wang

CONTACT

86-13802107048; wangjianing@buchangbio.com

Xinlei Guo

CONTACT

0086-10-87163362; guoxinlei@buchangbio.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 2, 2025
• First Posted: January 14, 2025
• Study Start: April 7, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 9, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)