Efficacy Evaluation of Avance QQ Collagen for Skin Beautification

NCT06771388 | Completed

• 1 other identifier: 24-088-B
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

To assess Avance QQ Collagen product on skin condition improvement

Conditions

Skin Condition; Liposomal Encapsulation

Keywords

Avance QQ Collagen; Double Nutri

Outcome Measures

Primary Outcomes (3)

• The change of skin collagen density

  DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units

  Change from Baseline skin collagen density at 8 weeks

• The change of skin wrinkles

  VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: the amount of detectable wrinkles

  Change from Baseline skin wrinkles at 8 weeks

• The change of skin elasticity

  Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units

  Change from Baseline skin elasticity at 8 weeks

Secondary Outcomes (4)

• The change of wrinkles around the eyes

  Change from Baseline wrinkles around the eyes at 8 weeks

• The change of skin hydration

  Change from Baseline skin hydration at 8 weeks

• The change of skin lightness

  Change from Baseline skin lightness at 8 weeks

• The change of skin tone

  Change from Baseline skin tone at 8 weeks

Other Outcomes (1)

• The change of self-assessment skin condition

  Change from Baseline skin condition at 8 weeks

Study Arms (3)

Placebo drink

PLACEBO COMPARATOR

Dietary Supplement: Placebo drink

Non-liposomal collagen drink

ACTIVE COMPARATOR

Dietary Supplement: Non-liposomal collagen drink

Liposomal collagen drink

EXPERIMENTAL

Dietary Supplement: Liposomal collagen drink

Interventions

Liposomal collagen drink DIETARY_SUPPLEMENT

consume 50 g liquid drink daily for 8 consecutive weeks

Also known as: Avance QQ Collagen

Liposomal collagen drink

Non-liposomal collagen drink DIETARY_SUPPLEMENT

consume 50 g liquid drink daily for 8 consecutive weeks

Non-liposomal collagen drink

Placebo drink DIETARY_SUPPLEMENT

consume 50 g liquid drink daily for 8 consecutive weeks

Placebo drink

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy male or female adults, age above 18 years old;
• The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023));
• Commitment not to use products having activity comparable with that of the product to be tested during the study period;
• Free of any dermatological or systemic disorder that would interfere with results.

You may not qualify if:

• Subject with obvious skin surface damage;
• Subject who had oral or topical medication which may affect skin condition within 1 month;
• Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product;
• Female who is pregnant, nursing or planning to become pregnant during the course of the study;
• Received facial laser therapy, chemical peeling in the past 2 months.

Sponsors & Collaborators

• TCI Co., Ltd.: lead

Study Sites (1)

Chia Nan University of Pharmacy & Science

Pingtung City, 928, Taiwan

Location

MeSH Terms

Conditions

Skin Diseases

Condition Hierarchy (Ancestors)

Skin and Connective Tissue Diseases

Study Officials

• Chia-Hua Liang, Ph.D.

  Chia Nan University of Pharmacy ＆ Science

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2025
• First Posted: January 13, 2025
• Study Start: November 1, 2024
• Primary Completion: January 24, 2025
• Study Completion: February 28, 2025
• Last Updated: April 13, 2025

Record last verified: 2025-04

Locations

TW (1)