Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer

NCT06767202 | Completed

• 1 other identifier: liukeqin0208
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore the association between phenol exposure and pregnancy outcome after embryo transfer. The main question it aims to answer \[is/are\]: Whether exposure to phenols is associated with adverse pregnancy outcomes in pregnant women undergoing assisted reproductive technology?

Conditions

Embryo Transfer

Keywords

Embryo Transfer; Dietary polyphenols; bisphenols

Outcome Measures

Primary Outcomes (1)

• Rate of clinical pregnancy patients

  Rate of biochemical pregnancy, clinical pregnancy and post-natal patients

  From the date of randomization until the termination of pregnancy

Secondary Outcomes (1)

• Rate of the health newborn

  From the date of randomization until the termination of pregnancy

Study Arms (1)

Pregnant women undergoing assisted reproductive technology in Tongji Hospital, Wuhan City, Hubei Pro

1. Chinese citizens over the age of 20; 2. IVF/ICSI assisted reproductive treatment in our center; 3. Complete clinical data, reproductive outcomes and questionnaire data of both sexes; 4. Knowing about this research and voluntarily accepting this research;

Eligibility Criteria

• Age: 20 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Pregnant women undergoing assisted reproductive technology in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China from 2024 to 2025

You may qualify if:

• Chinese citizens over the age of 20;
• IVF/ICSI assisted reproductive treatment in our center;
• Complete clinical data, reproductive outcomes and questionnaire data of both sexes;
• Knowing about this research and voluntarily accepting this research;

You may not qualify if:

• The patient receives sperm or egg donation treatment;
• The patient gave up the egg collection operation due to various reasons, and the cycle was canceled;
• The patient abandons treatment before achieving clinical pregnancy, but the fertile frozen embryo is not transferred;
• There are contraindications to pregnancy, such as serious liver and kidney diseases, malignant tumors, serious mental diseases, uncorrected coagulation function abnormalities or endocrine indicators abnormalities;
• Incomplete or missing clinical data or follow-up data;

Sponsors & Collaborators

• keqin liu: lead

Study Sites (1)

Reproductive center，tongji hospital，huazhong university of science and technology

Wuhan, Hubei, 430030, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Urine

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 6, 2025
• First Posted: January 9, 2025
• Study Start: March 14, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: July 18, 2025

Record last verified: 2025-07

Locations

CN (1)