Natural Cycles With Spontaneous Versus Induced Ovulation in FET
Frozen-Thawed Embryo Transfers: a Comparison Between Natural Cycles With Spontaneous or Induced Ovulation
1 other identifier
observational
2,866
0 countries
N/A
Brief Summary
In recent years, frozen-thawed embryo transfer procedure (FET) has been widely used to increase the cumulative pregnancy rate per IVF-cycle: which is the best preparation protocol remains a matter of debate. A retrospective analysis was conducted between 2012-2017. The aim was comparing clinical pregnancy rate (CPR) of pure natural cycle frozen-thawed embryo transfer (NC-FET) versus natural cycle frozen-thawed embryo transfer with hCG-triggered ovulation (mNC-FET).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2012
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 15, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2017
CompletedFirst Submitted
Initial submission to the registry
June 26, 2018
CompletedFirst Posted
Study publicly available on registry
July 10, 2018
CompletedJuly 19, 2018
June 1, 2018
3.5 years
June 26, 2018
July 17, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
CPR in NCFET vs mNCFET
compare the effectiveness in terms of better clinical pregnancy rates (CPR) of pure natural cycle frozen-thawed embryo transfer (NC-FET) versus natural cycle frozen-thawed embryo transfer modified by HCG administration
2012-2017
Study Arms (2)
NC-FET
pure natural cycle frozen-thawed embryo transfer
mNC-FET
modified natural cycle frozen-thawed embryo transfer by hCG administration
Interventions
Thawed embryo transfer with ovulation triggered by hCG
Eligibility Criteria
2866 cycles were included in the analysis. To limit potential confounders, only single blastocyst transfer cycles were included, vitrified on Days 5 or 6, excluding PGT-a cycles and cleavage stage embryo transfers.
You may qualify if:
- only single blastocyst transfer cycles were included
You may not qualify if:
- PGT-a cycles and cleavage stage embryo transfers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Levi Setti PE, Cirillo F, De Cesare R, Morenghi E, Canevisio V, Ronchetti C, Baggiani A, Smeraldi A, Albani E, Patrizio P. Seven Years of Vitrified Blastocyst Transfers: Comparison of 3 Preparation Protocols at a Single ART Center. Front Endocrinol (Lausanne). 2020 May 29;11:346. doi: 10.3389/fendo.2020.00346. eCollection 2020.
PMID: 32547496DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 26, 2018
First Posted
July 10, 2018
Study Start
January 1, 2012
Primary Completion
June 15, 2015
Study Completion
December 31, 2017
Last Updated
July 19, 2018
Record last verified: 2018-06
Data Sharing
- IPD Sharing
- Will not share